361389-85-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1H-Inden-1-amine,2,3-dihydro-4-methyl-(9CI) is used as a starting material for the synthesis of various pharmaceuticals and agrochemicals due to its aromatic amine structure, which can be further modified to create a range of active compounds.
Used in Solvent Applications:
Tetralin is used as a solvent for resins, varnishes, and waxes, taking advantage of its solubility in organic solvents and its ability to dissolve a variety of substances.
Used in Fragrance and Dye Production:
1H-Inden-1-amine,2,3-dihydro-4-methyl-(9CI) is used as a precursor in the production of fragrances and dyes, leveraging its aromatic properties to contribute to the development of scent and color compounds.
Health and Safety Considerations:
While tetralin is considered relatively low in toxicity, prolonged exposure to high concentrations may cause irritation to the eyes, skin, and respiratory system, necessitating appropriate safety measures during handling and use.

Upstream product

• 24644-78-8 4-methylindanone 
• 67864-03-3 4-methyl-2,3-dihydro-1H-inden-1-ol 
• 927406-13-1 1-azido-4-methyl-indane 

Relevant academic research and scientific papers

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

CHEMICAL COMPOUNDS

A compound of formula (I) where the substituents have the meanings assigned to them in claim 1 , compositions comprising a compound of formula (I) and the use of such compounds and/or compositions controlling insects, acarines, nematodes or molluscs.

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H- indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management

Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here we report that replacement of substituted benzyl groups by an indan rigid moiety in a previously described N-indazole-N′-benzyl urea series led to a number of TRPV1 antagonists with significantly increased in vitro potency and enhanced drug-like properties. Extensive evaluation of pharmacological, pharmacokinetic, and toxicological properties of synthesized analogs resulted in identification of (R)-7 (ABT-102). Both the analgesic activity and drug-like properties of (R)-7 support its advancement into clinical pain trials.

CHEMICAL COMPOUNDS

The use of a compound of formula (I) wherein X is (i), (ii) or (iii), formula (i),formula (ii), formula (iii) Y is O, S(O)m, NR3, CR5R6, CR5R6-CR7R8, O-CR7R