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• 100-01-6 4-nitro-aniline 
• 5683-78-3 8-hydroxy-7-quinolinecarboxaldehyde 

Relevant academic research and scientific papers

Stereochemistry of new nitrogen containing heterocyclic aldehyde. VII. Potentiometric, conductometric and thermodynamic studies of novel quinoline azodyes and their metal complexes with some transition metals

A novel series of quinoline azodyes (5-(4′-derivatives phenyldiazo)-8-hydroxy-7-quinolinecarboxaldehyde) (HL1-HL5) has been prepared and characterized by elemental analyses, 1H-NMR and IR spectra. The IR spectral data indicate that the compounds can exist in two resonance structures. Proton-ligand dissociation constants of quinoline azodyes and their subsituted derivatives, and metal-ligand stability constants of their complexes with bivalent (Mn2+, Co2+, Ni2+, Cu2+) metal ions have been determined potentiometrically in 0.1 M KCl and 40% (v/v) dimethylformamide (DMF)-water mixture. The influence of substituents on the dissociation and stability constants was examined on the basis of the electron repelling property of the substituent. The order of the stability constants of the formed complexes was found to be Mn2+2+2+2+. The effect of temperature was studied and the corresponding thermodynamic parameters (ΔG, ΔH, ΔS) were derived and discussed. The stoichiometries of these complexes were determined conductometrically and indicated the formation of 1:1 and 1:2 (metal:ligand) complexes was indicated.

Polymer complexes. LXXVIII. Synthesis and characterization of supramolecular uranyl polymer complexes: Determination of the bond lengths of uranyl ion in polymer complexes

The UO2(II) polymer complexes (1–5) of azo dye ligands 5(4`-derivatives phenylazo)-8-hydroxy-7-quinolinecarboxaldehyde (HLx) were prepared and characterized by elemental analysis, 1H NMR, IR spectra, thermal analysis and X-ray diffraction analysis (XRD). The molecular geometrical structures and quantum chemical of the ligands (HLx) and their tautomeric forms (D and G) were calculated. Molecular docking between the HLx ligands and their tautomeric form with two receptors of the breast cancer (1JNX) and the prostate cancer (2Q7K) was discussed. From the histogram of the HOMO–LUMO energy gap (ΔE) and the estimated free energy of binding of the receptors of prostate cancer (2Q7K) and breast cancer (1JNX) for the ligands (HLx), it is observed that the ΔE values of the ligands (HLx) increases in the order HL2?3?4?1?5. The electronic structures and coordination were determined from a framework for the modeling of the formed polymer complexes. From the IR spectra of the polymer complexes, the symmetric stretching frequency υ3 values of UO2 2+ were used for the determination of the force constant (FU-O (in 10?8?N/?)) and the bond length (RU-O (?)) of the U–O bond by using Wilson, G. F. matrix method, McGlynn & Badger's formula and El-Sonbati equations. The plot of the bond distance rU-O (r1, r2, r3, and rt) vs. υ3 was showed straight lines with increase in the value of υ3 and decrease in rU-O.

Synthesis, characterization, antimicrobial activity and ultrastructure of the affected bacteria of new quinoline compounds

The reaction on 8-hydroxy quinoline-7-aldehyde azo compounds (HLn) (where n?=?1–5) with 4-amino-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one to obtain HLn (where n?=?6–10) have been characterized by means of TLC, melting point and spectral data, such as IR, 1H NMR, mass spectra and thermal studies. The X-ray diffraction patterns of two starting materials 8-hydroxy quinoline-7-aldehyde (start 1), 4-amino-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (start 2) and the ligands (HL5,10) are investigated in powder form. All the ligands have been screened for their antimicrobial activity against four local bacterial species, two Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae) as well as against four local fungi; Aspergillus niger, Alternaria alternata, Penicillium italicum and Fusarium oxysporium. The results show that the azo ligands (HLn) (where n?=?1–5) have no antimicrobial activity against bacteria and fungi while most azomethine ligands (HLn) (where n?=?6–10) are good antibacterial agents against E. coli and K. pneumoniae as well as antifungal agents against P. italicum and A. alternata. The results were compared to standard substances (start 1) and (start 2). Among the azomethine ligands, HL10 was the most effective against the most microorganisms tested. The size of clear zone was ordered as p-(OCH3?3?2) as expected from Hammett’s constant (σR). Also, the ultrastructure study of the affected bacteria confirmed that HL8 is good antibacterial agent against E. coli and S. aureus.

Stereiochemistry of new nitrogen-containing heterocyclic aldehydes. XII. Supramolecular structures and properties models of ruthenium with quinoline azodyes

Novel bis- and tris-complexes of ruthenium(III) with 5-(4′ -derivative phenyldiazo)-8-hydroxy-7-quinolinecarboxaldehyde (HLn) have been characterised on the basis of elemental and thermal analysis, IR, magnetic and electronic spectral analysis as well as conductivity measurements. Electronic spectra show that all complexes are octahedral with chloride are attached to the metal ion in a 1:2 (metal:ligand) ratio. The spectral data were utilised to compute the ligand field parameters B, β and Dq. The B-values suggest a strong covalency in the metal-ligand σ-bond and the Dq-values indicate a medium-strong ligand field. It is apparent that the β values depend greatly upon the electronegativity of the donor atoms and the ligand structure and also the effect of the p-substituent groups. IR spectra indicate that the ligand is bidentate forming a six-membered chelating ring with concomitant formation of an intramolecular hydrogen bond. The ligands are present in associated form in solution via intermolecular hydrogen bonding. The effect of Hammett's constant on the ligand field parameters is also discussed.