36150-00-2 Usage
Description
5-TRANS PROSTAGLANDIN E2, also known as PGE2, is a naturally occurring eicosanoid derived from the metabolism of arachidonic acid. It is a bioactive lipid compound that plays a crucial role in various physiological processes, including inflammation, pain, and fever. Its unique structure and properties make it a valuable compound for research and development in the pharmaceutical and medical fields.
Used in Pharmaceutical Industry:
5-TRANS PROSTAGLANDIN E2 is used as a research compound for the isolation and synthesis of new naturally occurring prostaglandins, such as 5-trans-PGA2. This helps in the discovery and development of novel therapeutic agents with potential applications in treating various diseases and conditions.
5-TRANS PROSTAGLANDIN E2 is also used as a key intermediate in the synthesis of other bioactive prostaglandins, such as 5-trans-PGE2, 5-trans-PGF2a, and their 5,6-trans isomers. These synthesized compounds can be further utilized in the development of pharmaceutical drugs targeting specific medical conditions, such as inflammatory disorders, cardiovascular diseases, and reproductive health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 36150-00-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,1,5 and 0 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 36150-00:
(7*3)+(6*6)+(5*1)+(4*5)+(3*0)+(2*0)+(1*0)=82
82 % 10 = 2
So 36150-00-2 is a valid CAS Registry Number.
36150-00-2Relevant articles and documents
Preparation of ent-prostaglandin E2
Taber, Douglass F,Jiang, Qin
, p. 5991 - 5994 (2007/10/03)
The enantiomeric prostaglandins, exemplified by ent-PGE2, are apparently produced in vivo by the nonenzymatic oxidation of arachidonic acid. To assess the physiological activity of ent-PGE2, it was necessary to prepare it by total sy
Isolation of a new naturally occurring prostaglandin, 5-trans-PGA 2 . Synthesis of 5-trans-PGE 2 and 5-trans-PGF 2a .
Bundy,Daniels,Lincoln,Pike
, p. 2124 - 2124 (2007/10/06)
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Enzymatic preparation and purification of prostaglandin E2.
Lapidus,Grant,Alburn
, p. 371 - 373 (2007/10/16)
An enzymatic system has been developed for the production of prostaglandin E(2) (PGE(2)) from arachidonic acid by extracts of sheep seminal vesicular glands. The presence of glutathione insures high yields. A new procedure for the purification of PGE(2) was also developed, based on the dialysis of the biosynthesized product at pH 8 and extraction of the dialysate at pH 3 with chloroform. This procedure routinely gives yields of PGE(2) of 25-37% (from arachidonic acid) with a purity of 90-100%. Additional analytical proof of the identity of PGE(2) was provided by physicochemical characteristics of the crystalline thiosemicarbazide derivative, which can be readily prepared under mild conditions.
