36151-01-6

Basic information

• Product Name: 7,8-Dihydrovomifoliol
• Synonyms: (S)-4-Hydroxy-4-[(R)-3-hydroxybutyl]-3,5,5-trimethyl-2-cyclohexen-1-one;7,8-Dihydrovomifoliol;Blumenol B;Blumel B
• CAS NO: 36151-01-6
• Molecular Formula: C₁₃H₂₂O₃
• Molecular Weight: 226.31
• Mol File: 36151-01-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7,8-Dihydrovomifoliol(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-Dihydrovomifoliol(36151-01-6)
• EPA Substance Registry System: 7,8-Dihydrovomifoliol(36151-01-6)

Safety Data

• Hazardous Substances Data: 36151-01-6(Hazardous Substances Data)

Usage

General Description

7,8-Dihydrovomifoliol is a natural compound found in plants such as chamomile and feverfew. It belongs to the class of sesquiterpene lactones, which are known for their potential medicinal properties. 7,8-Dihydrovomifoliol has been investigated for its anti-inflammatory and anti-cancer activities, and has shown promise in reducing inflammation and inhibiting the growth of cancer cells in laboratory studies. Additionally, it has been studied for its potential to act as an antioxidant and protect against oxidative stress. The compound's unique chemical structure and biological activities make it a subject of interest in the field of natural product chemistry and pharmaceutical research.

Upstream product

• 114226-08-3 (+)-(6S,9R)-9-O-β-D-glucopyranosyloxy-6-hydroxy-3-oxo-α-ionol 

Downstream Products

• 1309362-82-0 (6S,9R)-6,9-dihydroxymegastigman-4-en-3-one 9-(S)-MTPA ester 
• 1309362-81-9 (6S,9R)-6,9-dihydroxymegastigman-4-en-3-one 9-(R)-MTPA ester 

Relevant articles and documents

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla

A phytochemical investigation on the MeOH extract of the twigs and needles of the endangered plant Picea brachytyla led to the isolation and characterization of thirty-eight structurally diverse terpenoids. Seven of these molecules are previously undescribed, including three abietane-type (brachytylins A–C) and one labdane-type (brachytylin D) diterpenoids, an unseparated C-24 epimeric mixture of cycloartane-type triterpenoids (brachytylins E/F, ratio: 1:1), and a rare rearranged 12(1 → 6)-abeo-megastigmane glycoside (brachytylins G). Their structures and absolute configurations were determined by extensive spectroscopic (e.g., detailed 2D NMR and ECD) methods and/or X-ray diffraction analyses. All the isolates were evaluated for their inhibitory activities against the adenosine triphosphate (ATP)-citrate lyase (ACL) and the Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). Among them, abiesadine J showed inhibitory effect against ACL, displaying an IC50 value of 17 μM. 3S,23R-Dihydroxycycloart-24-en-26-oic acid exhibited inhibitory effect on SHP2, with an IC50 value of 19 μM. Meanwhile, 3R*,23S*-dihydroxycycloart-24-en-26-oic acid was found to have inhibitory effects against both ACL and SHP2, with IC50 values of 16 and 12 μM, respectively.

Studies on the glycosides of Epimedium grandiflorum Morr. var. thunbergianum (Miq.) Nakai. III

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