361519-97-3

Upstream product

• 1623-08-1 phosphoric acid dibenzyl ester 
• 4703-32-6 (S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid 
• 361519-96-2 (2S,5S,6S,7S,8R,10aS)-octahydro-5-[(4-methoxyphenyl)methyl]-2-methylamino-1H-7,10a-methanopyrrolo[1,2-a]azocine-6,8-diol 
• 1395688-64-8 C₃₀H₄₈N₂O₆Si 
• 1395688-56-8 C₃₂H₄₄N₄O₄Si 
• 1395688-49-9 C₃₂H₄₅NO₄Si 
• 1395688-41-1 C₂₆H₃₁NO₄ 
• 1395688-32-0 C₂₆H₂₉NO₄ 
• 1395688-24-0 C₂₆H₂₇NO₄ 
• 1395688-17-1 C₁₈H₁₉NO₃ 
• 1395688-09-1 C₂₀H₂₃NO₄ 
• 1395688-01-3 C₂₂H₂₇NO₄ 
• 1416404-30-2 C₁₉H₂₅NO₃ 
• 1395687-93-0 C₂₂H₂₉NO₃ 

Downstream Products

• 248948-75-6 (2S,5S,6S,7R,8S,10aS)-2-[[(benzyloxy)carbonyl]methylamino]octahydro-6-hydroxy-5-[(4-methoxyphenyl)methyl]-1H-7,10a-methanopyrrolo[1,2-a]azocin-8-yl dibenzyl phosphate 

Relevant academic research and scientific papers

Enantioselective total syntheses of (-)-FR901483 and (+)-8- epi -FR901483

The enantioselective total syntheses of the potent immunosuppressant FR901483 (1) and its 8-epimer (47) have been accomplished. Our approach features the use of building block 6 as the chiron, the application of the one-pot amide reductive bis-alkylation method to construct the chiral aza-quaternary center (dr = 9:1), regio- and diastereoselective intramolecular aldol reaction to build the bridged ring, and RCM to form the 3-pyrrolin-2-one ring.

Synthetic ventures inspired by biosynthetic hypotheses: the evolution of a method for the oxidative amidation of phenols

We describe the development of a technique for the oxidative conversion of 4-alkyl phenols to derivatives of the corresponding 4-alkyl-4-amino-2,5-cyclohexanediones. This transformation, which was inspired by biogenetic considerations, constitutes a key s