36155-36-9Relevant articles and documents
Synthesis of 2,3,4,5-Tetrahydrobenzo[1,4]thiazepines via N-Acyliminium Cyclization
Deng, Shixian,Cheng, Zhenzhuang,Ingalls, Charles,Kontes, Ferenc,Yan, Jiaming,Belvedere, Sandro
, p. 1801 - 1805 (2017/11/24)
We report an efficient and scalable synthesis of 7-methoxy-2,3,4,5-tetrahydrobenzo[1,4]thiazepine, the core structure of biologically active molecules like JTV-519 and S107. This synthetic route, starting with 4-methoxythiophenol and proceeding via acyliminum cyclization, gives the target product in four steps and 68% overall yield and is a substantial improvement over previously published processes. Nine additional examples of tetrahydrobenzo[1,4]thiazepine synthesis via acyliminium ring closure are also presented.
Agents for treating disorders involving modulation of ryanodine receptors
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Paragraph 0107, (2013/11/05)
The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.
Oligomerization of ethylene using new tridentate iron catalysts bearing α-diimine ligands with pendant S and P donors
Small, Brooke L.,Rios, Ray,Fernandez, Eric R.,Gerlach, Deidra L.,Halfen, Jason A.,Carney, Michael J.
experimental part, p. 6723 - 6731 (2011/03/17)
Stoichiometric Schiff base condensations of sterically bulky primary amines with acenaphthenequinone yield isolable monoimines. In the presence of iron(II) chloride, the remaining ketone reacts with a second primary amine bearing a pendant donor atom to g
