36159-03-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(5,6-dimethoxy-2,3-dihydro-1H-inden-1-ylidene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one is used as an impurity in the synthesis of Donepezil (D531750), a nootropic drug. It plays a role in the production process of this medication, which is an inhibitor of acetylcholinesterase, a key enzyme involved in cognitive function. The presence of 2-(5,6-dimethoxy-2,3-dihydro-1H-inden-1-ylidene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one in the synthesis process may have implications for the purity and efficacy of the final product.

Upstream product

• 2107-69-9 5,6-dimethoxy-1-indanone 
• 5111-70-6 5-methoxy-1-indanone 

Relevant academic research and scientific papers

Borontribromide-mediated C-C bond formation in cyclic ketones: A transition metal free approach

Borontribromide (BBr3) is a well-known demethylating agent. The current investigation was focused on a new application of borontribromide as a C-C bond forming agent in cyclic ketones. In this study, borontribromide mediated C-C bond formation reactions of tetralones, chromenone, thiochromenone and indanones were explored. A methoxy group containing ketones showed selective C-C bond formation reaction instead of demethylation of the methoxy group. MM2 steric energy calculations for the final products showed that the reaction favored the formation of exo- or endo-cyclic double bond containing products, depending upon their low MM2 steric energy in a specific frame structure, as observed in X-ray crystallography. A comprehensive crystallographic and pi-stacking analysis of product 10a demonstrated the formation of 10a as an enantiomeric mixture, and its centre of inversion was stabilized by a set of three unique pi-pi interactions.

Indane dimerization products obtained by treatment of N-acylindan-1-amines with ethyl polyphosphate (EPP)

This report describes the diverse dimeric products obtained by treatment of N-acylindan-1-amines with ethyl polyphosphate in chloroform-diethyl ether solution at 80°C for 8 h. Possible mechanisms for such reactions are discussed.