3616-44-2Relevant academic research and scientific papers
A facile synthesis of dragmacidin B and 2,5-bis(6′-bromo-3′-indolyl)piperazine
Miyake, Fumiko Y.,Yakushijin, Kenichi,Home, David A.
, p. 3185 - 3187 (2000)
(matrix presented) A short synthesis of dragmacidin B (1), 2,5-bis(6′-bromo-3′-indolyl)piperazine (2), and corresponding didebromo analogues 8 and 9 is described. The key steps involve the dimerization of oxotryptamines 4 and 11 to give bis(indolyl)pyrazines 5 and 12, which upon selective reduction and reductive methylation with sodium cyanoborohydride afforded the requisite piperazine natural products.
