36163-86-7Relevant academic research and scientific papers
Asymmetric Synthesis of P-Stereogenic Phosphinic Amides via Pd(0)-Catalyzed Enantioselective Intramolecular C-H Arylation
Liu, Lantao,Zhang, An-An,Wang, Yanfang,Zhang, Fuqiang,Zuo, Zhenzhen,Zhao, Wen-Xian,Feng, Cui-Lan,Ma, Wenjin
, p. 2046 - 2049 (2015)
(Chemical Equation Presented). The palladium-catalyzed enantioselective intramolecular C-H arylation of N-(2-haloaryl)-P,P-diphenylphosphinic amides furnishes P-stereogenic phosphine oxide derivatives in 61-99% yield with 88-97% ee. The catalyst generated in situ from a TADDOL-derived phosphoramide ligand and Pd(dba)2 is optimum in terms of yield and enantioselectivities.
