36167-63-2

Basic information

• Product Name: Halofantrine hydrochloride
• Synonyms: Halofantarine HCL;Halfan, 1,3-Dichloro-a-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol hydrochloride;Halfan;D02485;Halfan (tn);Halofantrine hydrochloride (usan);Halfan Hydrochloride;9-PhenanthreneMethanol,1,3-dichloro-alpha-[2-(dibutylaMino)ethyl]-6-(trifluoroMethyl)-,hydrochloride (1:1)
• CAS NO: 36167-63-2
• Molecular Formula: C₂₆H₃₀Cl₂F₃NO*ClH
• Molecular Weight: 536.89
• EINECS: 252-895-4
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 36167-63-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 93-96°; mp 203-204°
• Boiling Point: 596.2°Cat760mmHg
• Flash Point: 314.4°C
• Appearance: white to off-white/
• Density: 1.244g/cm³
• Storage Temp.: 2-8°C
• Solubility: DMSO: >10mg/mL
• CAS DataBase Reference: Halofantrine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Halofantrine hydrochloride(36167-63-2)
• EPA Substance Registry System: Halofantrine hydrochloride(36167-63-2)

Safety Data

• WGK Germany: 3
• RTECS: SF7790000
• Hazardous Substances Data: 36167-63-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 36167-63-2 differently. You can refer to the following data:
1. Antimalarial.
2. halofantrine, a drug that is effective against chloroquine-resistant malaria and is now being evaluated in Africa.

Brand name

Halfan (GlaxoSmithKline).

InChI:InChI=1/C26H32Cl2F3NO.ClH/c1-3-5-12-32(13-6-4-2)14-11-24(33)25(28)17-20(27)16-22-21-15-19(26(29,30)31)9-7-18(21)8-10-23(22)25;/h7-10,15-16,24,33H,3-6,11-14,17H2,1-2H3;1H

Relevant articles and documents

Preparation method of halofantrine hydrochloride

The invention provides a preparation method of halofantrine hydrochloride. The method comprises the following steps: generating corresponding acyl chloride from 4-trifluoromethyl-2-(3, 5-dichlorophenyl) phenylacetic acid and an acylating chlorination reagent, carrying out Friedel-Crafts reaction cyclization, performing condensation with N, N-di-n-butyl-beta-aminopropionate, and finally, carrying out reduction, aromatization and salification to obtain the halofantralin hydrochloride. The method has the advantages of cheap and accessible raw materials and low cost; reaction conditions are easy to realize, the technological process and operation are safe, simple and convenient, less wastewater is generated, and environmental friendliness is achieved; and the intermediate is good in stability,the reaction activity and selectivity are high, there are fewer side reactions, and the prepared halofantrine hydrochloride is few in impurity, high in purity and high in yield.