36176-40-6Relevant academic research and scientific papers
2-AMINOOXAZOLINES AS TAAR1 LIGANDS
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Page/Page column 18, (2010/12/29)
The invention relates to compounds of formula (I) wherein R1 is halogen; R2 is lower alkyl or lower alkyl substituted by halogen; R2' is hydrogen, lower alkyl or lower alkyl substituted by halogen; X is a bond, -CH2-, -CH2CH2- or -CH2CH2CH2-; Y is phenyl or cyclohexyl; and n is 0, 1 or 2; or to a pharmaceutically suitable acid addition salt thereof. The compounds of formula I are active on the TAAR1 receptor and are therefore suitable for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
Phenylation reaction of α-acylnitromethanes to give 1,2-diketone monooximes: Involvement of carbon electrophile at the position a to the nitro group
Takamoto, Mikihiro,Kurouchi, Hiroaki,Otani, Yuko,Ohwada, Tomohiko
experimental part, p. 4129 - 4136 (2011/03/17)
The generality and the effects of substituents on phenylation reactions of α-acylnitromethanes catalyzed by trifluoromethanesulfonic acid have been studied. α-Aroylnitromethanes afforded benzil monooximes in good yield. In the case of aliphatic α-acylnitromethane, a similar phenylation reaction proceeded, but the yield of the phenylated 1,2-dione monooxime was low. These phenylation reactions represent examples of the generation of carbocation electrophiles at the α-position of a nitro group. Georg Thieme Verlag Stuttgart - New York.
ISOQUINOLINE SYNTHESIS VIA 2-OXAZOLINES. PART VI. TRANSFORMATION OF 1-BENZAMIDO-1-PHENYL-2-ALKANOLS INTO 4-ALKYL-1-PHENYLISOQUINOLINES
Kopczynski, Tomasz,Krzyzanowska, Ewa
, p. 471 - 482 (2007/10/02)
Conditions necessary for the transformation of 1-benzamido-1-phenyl-2-alkanols (1) and 5-alkyl-2,4-diphenyl-2-oxazolines (2) into 4-alkyl-1-phenylisoquinolines (3) have been determined.The mechanism proposed for these reactions is supported by the results
