36186-74-0

Usage

Molecular structure

1H-Cyclopropa[a]naphthalene-1-carboxylic acid, 1a,2,3,7b-tetrahydro-, ethyl ester is a complex organic compound with a bicyclic structure, featuring both a cyclopropane ring and a naphthalene ring.

Ethyl ester derivative

The compound is an ethyl ester derivative of cyclopropa[a]naphthalene-1-carboxylic acid, indicating the presence of an ester functional group formed by the reaction of the carboxylic acid with ethanol.

Potential applications

Due to its unique structure and properties, the compound could be used in the synthesis of other organic compounds or as a starting material for the development of new pharmaceuticals or agrochemicals.

Physical properties

The specific physical properties of 1H-Cyclopropa[a]naphthalene-1-carboxylic acid, 1a,2,3,7b-tetrahydro-, ethyl ester are not provided, but may include characteristics such as melting point, boiling point, and solubility.

Chemical properties

The chemical properties of 1H-Cyclopropa[a]naphthalene-1-carboxylic acid, 1a,2,3,7b-tetrahydro-, ethyl ester are not fully known, but may include reactivity, stability, and the ability to undergo specific chemical reactions or transformations.

Biological properties

The biological properties of 1H-Cyclopropa[a]naphthalene-1-carboxylic acid, 1a,2,3,7b-tetrahydro-, ethyl ester are not detailed, but could include potential interactions with biological systems, such as enzymes, receptors, or cellular processes.

Further research

To fully understand the potential uses and properties of 1H-Cyclopropa[a]naphthalene-1-carboxylic acid, 1a,2,3,7b-tetrahydro-, ethyl ester, additional research and testing would be necessary, including the investigation of its physical, chemical, and biological properties, as well as potential applications in various fields.

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 447-53-0 1,2-Dihydronaphthalene 

Downstream Products

• 31481-66-0 1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalene-1-carboxylic acid 

Relevant academic research and scientific papers

Catalytic cyclopropanation, antimicrobial, and DFT properties of some chelated transition metal(II) complexes

Transition Metal (II) complexes of general formula [MII(NH2C2H4NH2)3][B(C6F5)4]2 (1-6), where (M= Mn, Fe, Co, Ni, Cu, Zn) have been synthesized and characterized in the solid state and in solution using elemental, thermogravimetric analysis, EPR, 11B-NMR and IR spectroscopy. All complexes were used as catalysts for the cyclopropanation reaction with a variety of olefins. Excellent yields up to 93% were obtained using complex 5. All prepared complexes were used as anti-bacterial agents against different types of bacteria (Gram-negative and Gram-positive), and as anti-fungal agents. Complex 6 showed the highest activity with MIC value of 8 μg/mL against Staphylococcus aureus (Gram-positive bacteria), and of 16 μg/mL against candida albicans. To get more insights into their structural features, molecular geometries of all prepared complexes were fully optimized using density functional theory calculations at the M06-2X/6-311+G** level of theory.

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

Compounds of the formula I: where; R1 is O, S; R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond; R3 is H, C1-C3 alkyl, R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, haloC1-C6 alkyl, C1-C6 alkanoyl, haloC1-C6 alkanoyl, C1-C6 alkoxy, haloC1-C6 alkoxy, C1-C6 alkyloxy-C1-C6 alkyl, haloC1-C6 alkyloxy-C1-C6 alkyl hydroxy-C1-C6 alkyl, amino-C1-C6 alkyl, carboxy-C1-C6 alkyl, cyano-C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto; X is —(CR8R9)n— R8 and R9 are independently H, C1-C3 alkyl, OH or R8 and R9 together are ═O n is 1, 2 or 3 and prodrugs and pharmaceutically acceptable salts thereof, have utility as inhibitors of HIV-1 reverse transcriptase, particularly drug escape mutants.

Cyclopropanation reactions catalysed by rhodium(I) complexes with new anionic carborane phosphine ligands

The first set of rhodium(I) complexes 1-3 has been shown to be active for the cyclopropanation of olefins with diazoaeetates.

[OsH4(PPh3)3]: New catalyst for the selective cyclopropanation of activated olefins

The title compound was found to be an efficient catalyst for the selective cyclopropanation of activated olefins by ethyl diazoacetate. The cyclopropane yields range from moderate to good (75 to 95%) for activated olefins such as styrene and styrene derivatives, but are rather low (20 to 30%) for non-activated olefins such as terminal and cyclic alkenes. In the intermolecular competition, styrene was 45 times more reactive than cyclooctene. In all cases, trans (exo) cyclopropane predominated over the cis (endo) isomer.