3619-91-8

Usage

Uses

Used in Coordination Chemistry:
1,3-BIS(PHOSPHINO)PROPANE is used as a ligand for its ability to chelate with metal ions, providing stability to metal complexes and facilitating various chemical reactions.
Used in Catalysis:
In the field of catalysis, 1,3-BIS(PHOSPHINO)PROPANE is utilized as a ligand to enhance the efficiency of catalytic processes by stabilizing transition metal catalysts.
Used in Pharmaceutical Synthesis:
1,3-BIS(PHOSPHINO)PROPANE is used as a key component in the synthesis of pharmaceuticals, contributing to the development of new drugs and improving the manufacturing processes of existing ones.
Used in Agrochemical Production:
1,3-BIS(PHOSPHINO)PROPANE is also employed in the production of agrochemicals, where its properties aid in the synthesis of pesticides and other agricultural chemicals, enhancing crop protection and yield.
Used in Industrial Chemical Processes:
1,3-BIS(PHOSPHINO)PROPANE is used in various industrial chemical processes, where its versatility and ability to stabilize metal complexes are leveraged to improve reaction outcomes and product quality.

Upstream product

• 142-28-9 1,3-Dichloropropane 
• 7803-51-2 phosphan 
• 109-64-8 1,3-dibromo-propane 
• 22401-25-8 1,3-bis(diethoxyphosphinyl)propane 
• 64630-19-9 tetrabutyl propane-1,3-diylbis(phosphonate) 

Downstream Products

• 28240-70-2 1,3-Propandiylbis(dichlorphosphan) 

Relevant academic research and scientific papers

A CATALYST FOR THE CARBONYLATION OF ALKENES

The present application relates to a metal complex of Formula (I) and a catalyst composition for the carbonylation of alkenes comprising the metal complex, wherein the metal is a group 10 element such as palladium, platinum or nickel, and the complex comprises a bidentate phosphine ligand. The present invention also relates to a process for the preparation of a dicarboxylic acid or ester thereof from an alkenoic acid or ester thereof, or a process for the preparation of a carboxylic acid or ester thereof from an alkene or alkenoic acid with high selectivity and activity using said metal complex or catalyst composition. The present application also relates to a method of preparing Nylon 6-6 comprising the step of copolymerising adipic acid with hexamethylenediamine.

Highly fluorous bidentate phosphines

The reaction of tetrachlorodiphosphines [Cl2P(CH 2)nPCl2; n = 2-4] with fluorous aromatic precursors 4-bromo(perfluorohexyl)benzene and 4-(perfluorohexyl)phenol gave a series of fluorous-tagged diphosphines [(p-C6F13C 6H4)2P(CH2)nP(C 6H4C6F13-p)2; n = 2-4] and a new diphosphonite [(p-C6F13C6H 4O)2P(CH2)3P(OC6H 4C6F13-p)2]. The improved synthesis of 1,3-bis(dichlorophosphino)propane (dcpp), involved the facile chlorination of the corresponding primary phosphine with triphosgene. Fluorinated diimines RN=C(CH3)C(CH3)=NR, where R = p-C6H 4C6F13 or P-C6H4C 8F17 have also been prepared, and were found to be air-stable alternatives to the highly air-sensitive phosphorus-containing ligands. All compounds were characterised by a variety of techniques including NMR, IR, MS and microanalysis. The successful reduction of the phosphine-oxides [(p-C6F13C6H4)2P(O) (CH2)nP(O)(C6H4C6F 13-p)2; n = 2,3] with phenylsilane is also presented. Georg Thieme Verlag Stuttgart.

Catalyst system and method for carbonylation

The invention relates to a catalyst system for carbonylating olefinically or acetylenically unsaturated compounds with carbon monoxide and a nucleophile compound, containing (a) palladium; (b) a phosphine and (c) a polymer containing nitrogen which is soluble in the reaction mixture, with the exception of polyvinyl polymers with aromatic radicals containing nitrogen on the polymer chain. The invention also relates to a method for carbonylation in the presence of one such catalyst system.

Medium-ring diphosphines from diphosphabicycloalkanes: stereoselective syntheses, structure and properties

A series of 1,k+2-diphosphabicycloalkanes 2b-e are prepared by n-BuLi-promoted cyclisation of 1,ω-diphosphinoalkanes, followed by alkylation and cycloalkylation with 1,ω-dihaloalkanes.These compounds appear to be exclusively cis-isomers except 1,6-diphosphabicycloundecane 2e which is a 3:1 cis/trans mixture.Mono-quaternisation of cis-1,k+2-diphosphabicycloalkanes, followed by treatment of the mono-quaternary salts with alkyllithium or Grignard reagents produces cis-1,n-disubstituted-1,n-diphosphacycloalkanes 4 exclusively; examples containing 8-, 9- and 10-membered rings and a range of substituents on phosphorus are described.Di-quaternisation of 1,k+2-diphosphabicycloalkanes, followed by hydrolysis, yields the trans-isomers of 1,n-disubstituted-1,n-diphosphacycloalkane monooxides 6 exclusively; reduction of these with LiAlH4 in benzene gives largely trans-1,n-disubstituted-1,n-diphosphacycloalkanes 7, but is not completely stereoselective.The structure and properties of these diphosphacycloalkanes are discussed.He(I) photoelectron spectra of 1,5-diphosphabicyclooctane, 1,6-diphosphabicyclononane and 1,6-diphosphabicyclodecane show little evidence of interaction between phosphorus lone pairs, unlike the corresponding hydrazines.The medium-ring diphosphacycloalkanes, 1,5-dimethyl-1,5-diphosphacyclooctane and 1,6-dimethyl-1,6-diphosphacyclodecane also show little evidence of interaction between phosphorus lone pairs.

Synthesis of Primary and Secondary Phosphines by Selective Alkylation of PH3 under Phase Transfer Conditions

Primary phosphines, RPH2, may be synthesized selectively by alkylation of phosphine, PH3, with alkyl halides RX (R = Me, Et, n-Bu, 2-Bu, C16H33, CH2=CH-CH2, Ph-CH2, 2-Py-CH2-CH2; X = Cl, Br) and concentrated aqueous KOH as auxilliary base in dimethylsulfoxide as a solvent or in two phase systems employing phase transfer catalysts.Under more rigorous conditions secondary phosphines R2PH (R = Me, n-Bu, CH2=CH-CH2) are also acessible in good yields.Using 1,3-dibromo(chloro)-propane or -butane diprimary phosphines H2P-(CH2)2-CHR-PH2 (R = H, Me) are obtaines, while 1,4-dibromopentane in a high yield cyclization reaction leads to 2-methylphospholane (12) with a chiral C-atom in α-position.