36192-16-2

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 99-55-8 2-methyl-5-nitroaniline 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 91974-32-2 (6-Nitro-indolyl-3)-glyoxylsaeure-ethylester 
• 90947-21-0 6-nitroindole-3-glyoxylic acid 
• 133053-91-5 methyl 6-nitroindole-3-glyoxylate 
• 10553-13-6 6-nitro-1H-indole-3-carboxaldehyde 
• 133053-90-4 methyl 3-(4-nitro-2-dimethylaminomethyleneaminophenyl)-pyruvate 
• 99-55-8 2-methyl-5-nitroaniline 
• 77252-56-3 N-(2-methyl-5-nitrophenyl)formamide 

Relevant academic research and scientific papers

Formamidine as a versatile protecting group for primary amines: A mild procedure for hydrolytic removal

A mild, zinc chloride-promoted cleavage of N,N,-dimethyl-formamidine derivatives of primary amines to the free amines is described. Under slightly different hydrolytic conditions the corresponding N-formyl derivatives can be isolated.

Synthesis of Indoles via Ring Closure of 2-Alkylnitroaniline Derivatives.

A variety of nitroindoles have been prepared from imidate, amidine, and sec-anilide derivatives of 2-alkyl-3- or 5-nitroanilines by a base-induced cyclization promoted by dialkyl oxalates.It is shown that essentially the same procedure also can be used to synthesize the corresponding nitroindole-3-glyoxylates in one simple operation.The synthetic potential is discussed and a mechanism is proposed.