362003-83-6 Usage
Uses
Used in Pharmaceutical Industry:
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide is used as a ceramide kinase inhibitor for its potential role in treating cancer. It has shown to inhibit breast and lung cancer cell proliferation by inducing M phase arrest and effectively block cell migration and invasion in pancreatic and breast cancer cells.
Used in Cancer Research:
In the field of cancer research, N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide is utilized as a valuable tool for studying the role of ceramide kinase in cancer cell biology and its potential as a therapeutic target for various types of cancer.
Used in Drug Development:
NVP-231 is employed in the development of novel therapeutic strategies for cancer treatment, particularly in the design of inhibitors targeting ceramide kinase, which may lead to the discovery of new anticancer drugs with improved efficacy and selectivity.
References
Graf et al. (2008), Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor; Mol. Pharmacol., 74 925
Pastukhov et al. (2014), The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death; Br. J. Pharmacol., 171 5829
Rivera et al. (2016), Ceramide-1-phosphate regulates cell migration and invasion of human pancreatic cancer cells; Biochem. Pharmacol., 102 107
Schwalm et al. (2020), Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI3-Kinase and Akt; Int. J. Mol. Sci., 21 1396
Check Digit Verification of cas no
The CAS Registry Mumber 362003-83-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,2,0,0 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 362003-83:
(8*3)+(7*6)+(6*2)+(5*0)+(4*0)+(3*3)+(2*8)+(1*3)=106
106 % 10 = 6
So 362003-83-6 is a valid CAS Registry Number.
362003-83-6Relevant academic research and scientific papers
Cermide Kinase Modulation
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Page/Page column 18, (2009/07/17)
A compound of formula (I) wherein R1 is a straight chain, branched or cyclic aliphatic, aromatic or heterocyclyl group comprising at least 8 carbon atoms, e.g. 8 to 22, R2 is a straight chain, branched or cyclic aliphatic, aromatic o
