362045-82-7Relevant academic research and scientific papers
Two New Anti-Tumor Promoting Serratane-Type Triterpenoids from the Stem Bark of Picea jezoensis var. jezoensis
Tanaka, Reiko,Ishikawa, Yohei,Minami, Toshifumi,Minoura, Katsuhiko,Tokuda, Harukuni,Matsunaga, Shunyo
, p. 1041 - 1047 (2003)
Two new serratane-type triterpenoids, 1 and 2, were isolated from the stem bark of Picea jezoensis Carr. var. jezoensis (Pinaceae). Their structures were determined to be 3β-methoxyserrat-13-en-21β-ol (1) and 13/3, 14β-epoxy-3β-methoxyserratan-21β-ol (2) on the basis of spectroscopic methods and partial syntheses. Compounds 1 and 2 and their acetates were screened as potential anti-tumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. IC50 value evaluation showed that compound 1 was more effective than others. In addition, compounds 1 and 2 were examined for anti-tumor promoting activities in a two-stage carcinogenesis assay of mouse skin tumors induced by 7,12-dimethylbenz[a] anthracene (DMBA) as an initiator and TPA as a promoter. Compounds 1 and 2 exhibited significant anti-tumor promoting effects on mouse skin carcinogenesis.
