362052-45-7

Upstream product

• 25145-43-1 2-phenylpropionyl chloride 
• 1775-95-7 2-amino-5-nitrobenzophenone 

Downstream Products

• 366456-64-6 N-[[3-benzoyl-4-(2-phenylpropylamino)]phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide 
• 357436-75-0 N-(4-amino-2-benzoylphenyl)-2-phenylpropionic acid amide 

Relevant academic research and scientific papers

Structure-activity relationships of novel anti-malarial agents: Part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

We have developed the [5-(4-nitrophenyl)-2-furyl]acrylic acid substituted benzophenone 4g as a novel lead for anti-malarial agents. Here, we demonstrated that the acyl residue at the 2-amino group of the benzophenone core structure has to be a phenylacetic acid substructure substituted in its para-position with methyl or other substituents of similar size. The trifluoromethyl substituted derivative displayed an IC50 of 47 nM against the multi-drug resistant Plasmodium falciparum strain Dd2.

Use of 2-phenylene diamine derivatives for the treatment of infections

The invention relates to the use of compounds of formula (I), wherein n=0-3; R1, R2=H, alkyl, aryl, heteroaryl, acyl; R3=H, halogen, alkyl, aryl, heteroaryl, arylalkyl, acyl, CN, NO2, R4—X—; R4/

Synthesis, molecular modeling, and structure - Activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors

Because of the involvement of farnesylated proteins in oncogenesis, inhibition of the protein-modifying enzyme farnesyltransferase is considered a major emerging strategy in cancer therapy. Here, we describe the structure - activity relationship of a nove