36210-53-4

Upstream product

• 14371-84-7 4,4′-dimethoxy-2,2′-dinitro-diphenyl disulfide 
• 2941-69-7 5-methoxy-2-methylbenzo[d]thiazole 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 54346-87-1 2-amino-5-methoxybenzothiazole 
• 14482-32-7 2-amino-4-methoxybenzenethiol 

Downstream Products

• 91166-81-3 bis-(4-metossi-2-N-pirrolilfenil)disolfuro 
• 1579296-07-3 5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione 
• 14482-32-7 2-amino-4-methoxybenzenethiol 
• 31860-05-6 5-methoxy-1,2,3-benzothiadiazole 
• 91166-87-9 1-<5-metossi-2-(β,β-dimetossi-α-feniletiltio)fenil>pirrolo 
• 91166-84-6 1-(2-mercapto-5-metossifenil)pirrolo 

Relevant academic research and scientific papers

Electronic Modifications of Fluorescent Cytidine Analogues Control Photophysics and Fluorescent Responses to Base Stacking and Pairing

The rational design of fluorescent nucleoside analogues is greatly hampered by the lack of a general method to predict their photophysics, a problem that is especially acute when base pairing and stacking change fluorescence. To better understand these effects, a series of tricyclic cytidine (tC and tCO) analogues ranging from electron-rich to electron-deficient was designed and synthesized. They were then incorporated into oligonucleotides, and photophysical responses to base pairing and stacking were studied. When inserted into double-stranded DNA oligonucleotides, electron-rich analogues exhibit a fluorescence turn-on effect, in contrast with the electron-deficient compounds, which show diminished fluorescence. The magnitude of these fluorescence changes is correlated with the oxidation potential of nearest neighbor nucleobases. Moreover, matched base pairing enhances fluorescence turn-on for the electron-rich compounds, and it causes a fluorescence decrease for the electron-deficient compounds. For the tCO compounds, the emergence of vibrational fine structure in the fluorescence spectra in response to base pairing and stacking was observed, offering a potential new tool for studying nucleic acid structure and dynamics. These results, supported by DFT calculations, help to rationalize fluorescence changes in the base stack and will be useful for selecting the best fluorescent nucleoside analogues for a desired application.

Thiazole-containing propyne amide derivative as well as preparation method and pharmaceutical composition and application thereof

The invention relates to propynamide derivatives shown in a formula I as well as pharmaceutically acceptable salt and preparation method thereof, a composition containing one or more of the compounds, and an application of the compounds to treatment of tu

HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF

Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.

Facile net cycloaddition approach to optically active 1,5-benzothiazepines

The 1,5-benzothiazepine moiety is well-known as a versatile pharmacophore, and its derivatives are expected to have antagonism against numerous diseases. Thus, it is desirable to develop a synthetic route that enables facile enantioselective preparation of a wide range of such derivatives. Although the cycloaddition approach could be considered a possible route to these compounds, to date, there has been no precedent of such a protocol. We therefore present the first example of a highly enantioselective net [4 + 3] cycloaddition to afford 1,5-benzothiazepines by utilizing α,β-unsaturated acylammonium intermediates generated by chiral isothiourea catalysts, which undergo two sequential chemoselective nucleophilic attacks by 2-aminothiophenols. This protocol provided cycloadducts in extremely high regioselectivity, with a good-to-excellent stereoselectivity being achieved regardless of the steric and electronic properties of the substrates. This method therefore offers promising synthetic routes for the construction of a library of optically active 1,5-benzothiazepines for assay evaluation.

Functionalized tricyclic cytosine analogues provide nucleoside fluorophores with improved photophysical properties and a range of solvent sensitivities

Tricyclic cytosines (tC and tCO frameworks) have emerged as a unique class of fluorescent nucleobase analogues that minimally perturb the structure of B-form DNA and that are not quenched in duplex nucleic acids. Systematic derivatization of th

RICERCHE SU COMPOSTI AD ATTIVITA PSICOTROPA. Nota VIII - Sintesi ed attivita sedativa di alcuni derivati 9-sostituiti della 5-fenilpirrolobenzotiazepina e della cis-4,5-diidro-4-idrossi-5-fenilpirrolobenzotiazepina

Syntheses of 9-chloro-, 9-trifluoromethyl- and 9-methoxy-5-phenylpyrrolobenzothiazepine (II a-c) and of cis-9-chloro- and cis-9-trifluoromethyl-4,5-dihydro-4-hydroxy-5-phenylpyrrolobenzothiazepine with the respective acetyl derivat