36226-14-9

Upstream product

• 24543-03-1 5-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4,6-(5H,7H)-dione 
• 74-88-4 methyl iodide 
• 4439-54-7 N-cyclohexan-1-(furan-2-yl)methanamine 
• 21878-48-8 N-(2-furfuryl)-p-ethoxyaniline 
• 61541-41-1 6-azido-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 114142-95-9 6-[(4-Ethoxy-phenyl)-furan-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 116360-56-6 1,3-Dimethyl-2,4-dioxo-6-(thiophen-2-ylmethyl-p-tolyl-amino)-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 3139-30-8 N-((thiophene-2-yl)methyl)-4-methylbenzeneamine 
• 182358-34-5 6-[(4-Ethoxy-phenyl)-furan-2-ylmethyl-amino]-1,3-dimethyl-5-(phenyl-hydrazonomethyl)-1H-pyrimidine-2,4-dione 
• 182358-38-9 6-(Ethyl-furan-2-ylmethyl-amino)-1,3-dimethyl-5-(phenyl-hydrazonomethyl)-1H-pyrimidine-2,4-dione 
• 182358-37-8 6-(Furan-2-ylmethyl-methyl-amino)-1,3-dimethyl-5-(phenyl-hydrazonomethyl)-1H-pyrimidine-2,4-dione 
• 89549-87-1 6-azido-1,3-dimethyl-5-formyluracil 
• 100-63-0 phenylhydrazine 
• 182358-24-3 6-(Benzyl-furan-2-ylmethyl-amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 

Relevant academic research and scientific papers

Studies on pyrimidine-annelated heterocycles: Synthesis of novel pyrazolo[3′,4′:4,5]pyrido[2,3-d]pyrimidines by intramolecular 1,3-dipolar cycloadditions

Suitably functionalised 1,3-substituted 6-chloro-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbaldehydes 3a-l cyclise intramolecularly to yield novel furo- and thieno-[2″,3″:4′,5′]pyrazolo[3′,4′:4,5] pyrido-[2,3-d]pyrimidines 8a-l in fair to good yields to

Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors

Two modes of tethering a chiral (phenylisopropyl)amino substituent in pyrazolo[3,4-d]pyrimidines and purines have been explored. One mode gave (S)- 2,7-dihydro-7-phenyl-2-(phenylmethyl)-5-propoxy-3H-imidazo[1,2-c]pyrazolo- [4,3-e]pyrimidine (12a) and its corresponding R-enantiomer 12b, which were selective for A2 and A1 adenosine receptors, respectively. The corresponding diimidazo[1,2-c:4',5'-e]pyrimidines 12e and 12f were analogously selective. This is the first example where a single chiral recognition unit provides enantiomers with opposite selectivities for adenosine receptors. The second mode gave (2S-trans)-2,7-dihydro-2-methyl- 3,7-diphenyl-5-propoxy-3H-imidazo[1,2-c]-pyrazolo[4,3-e]pyrimidine (12c) and its corresponding R-enantiomer 12d. Compounds 12c and 12d were significantly less potent than 12a and 12b at A1 receptors, and were nonselective.

Pyrimidine Derivatives and Related Compounds. XLVI. Thermal and Photochemical Transformation of 5-Substituted 6-Azido-1,3-dimethyluracils into Fused Pyrimidines such as Isoxazolopyrimidines, Pyrazolo-pyrimidines, and Pyrimido-t

Thermolysis and photolysis of 6-azido-1,3-dimethyluracils possessing certain substituents (formyl, benzoyl, hydrazonomethyl, phenyl, and benzyl groups) at the 5-position provided new methods for the preparation of fused pyrimidines.Irradiation and heating