36237-80-6Relevant articles and documents
An efficient solventless synthesis of cycloalkeno-1,2,3-selenadiazoles, their antimicrobial studies, and comparison with parent semicarbazones
Jadhav, Aditi A.,Dhanwe, Vaishali P.,Joshi, Prasad G.,Khanna, Pawan K.
, p. 102 - 106 (2015/03/18)
[Figure not available: see fulltext.] A series of heterocyclic organoselenium compounds, cycloalkeno-1,2,3-selenadiazoles (cyclopenteno, cyclohexeno, cyclohepteno, and cycloocteno-1,2,3-selenadiazoles), was synthesized at room temperature in one step under solventless conditions from the corresponding semicarbazones. The synthesized 1,2,3-selenadiazoles and their parent semicarbazones were screened for their antimicrobial activity against various pathogenic bacteria using agar disc diffusion method. All compounds were found active against E. coli, S. aureus, S. typhi, and P. aeruginosa. Among all the tested selenadiazoles, cyclopenteno-1,2,3-selenadiazole showed excellent inhibition against highly resistant P. aeruginosa. It is observed that selenadiazoles showed higher activity compared with the respective semicarbazones.
