36241-14-2Relevant academic research and scientific papers
Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
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, (2008/06/13)
The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of pla
Mono-and dihydrophosphoranes and dihydrophosphoranates as intermediates in the reaction of phosphonium salts with LiAiH4
Donoghue, Neil,Gallagher, Michael J.
, p. 169 - 173 (2007/10/03)
Reduction of tetraphenylphosphonium bromide with LiAlH(D)4 at room temperature affords first the monohydrophosphorane Ph4PH, then the dihydrophosphoranate anion [Ph4PH2]- which decomposes to the dihydrophosphorane Ph3PH2, all of which are identified by 31PNMR. Reductions of other phosphonium salts appear to follow a similar path. At elevated temperatures none of these intermediates is observed and attempted isolation leads to extensive decomposition.
Optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids and pharmaceutical use thereof
-
, (2008/06/13)
The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of pla
Halogenated tetraenyl prostaglandin derivatives
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, (2008/06/13)
The present invention relates to a novel class of halogenated tetraenyl prostaglandin compounds represented by the following general formula STR1 or a pharmaceutically acceptable salt thereof, wherein Y is --CH=CH-- or --CH2 --CH2 --; R1 is H or a lower alkyl of 1 to 6 carbons; n is an integer from 0 to 3; m is an integer from 0 to 3 and n+m=3; X is Cl or F provided that when X is Cl, n is 2 and m is 1; R2 and R3 are independently H, lower alkyl from 1 to 6 carbons, Cl, --CH2 Cl, --CH2 F, --CHCl2, --CCl3, or taken together form a cycloalkyl of 3 to 6 carbons; R4 is H, lower alkyl from 1 to 6 carbons, Cl, F or taken together with R3 form a cycloalkenyl of 4 to 6 carbons; and provided that at least one of --CHn Xm, R2, R3 and R4 includes a chlorine or fluorine atom.
7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives, their use and preparation
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, (2008/06/13)
7-Oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives of formula (I): STR1 (in which:) R1 represents a hydrogen atom or an optionally substituted alkyl group; X represents an oxy group, a thio group, a sulphinyl group or a sulphonyl group; A represents a bivalent for trivalent saturated aliphatic hydrocarbon group; p is 1 (when A is bivalent) or 2 (when A is trivalent); R2 represents an azido, nitro or cyano group or one of the groups of formula STR2 m and n are the same or different and each is 0 or 1; R represents an amidino group or a group of formula R4, --N(R4)2 or --YR4, B represents a group of formula STR3 D represents a group of formula STR4 (provided that, where m and n are both 1, the groups represented by B and D must be different); R4 represents a hydrogen atom or an alkyl group and, where there are 2 or more groups represented by R4, they may be the same or different, and Y represents an oxygen atom or a sulphur atom; and R3 represents a carboxy group or a protected carboxy group) and pharmaceutically acceptable salts thereof are valuable antibiotics and may be prepared by a process which includes heating a corresponding phosphorus-ylide compound.
Novel prostanoic acid derivatives and process for the preparation thereof
-
, (2008/06/13)
Prostaglandins of the formula STR1 wherein R1 is hydroxymethyl, carboxy, aryloxycarbonyl, alkoxycarbonyl of 1-8 carbon atoms in the alkoxy group, or the group -COO-CH2 -U-V wherein U is a direct C-C bond, carbonyl or carbonyloxy and
