362483-07-6Relevant academic research and scientific papers
Reactivity of acyclic (pentadienyl)iron(1+) cations with phosphonate stabilized nucleophiles: Application to the synthesis of oxygenated metabolites of carvone
Lee, Do W.,Manful, Charles F.,Gone, Jayapal Reddy,Ma, Yuzhi,Donaldson, William A.
, p. 753 - 759 (2016)
The addition of phosphonate stabilized carbon nucleophiles to acyclic (pentadienyl)iron(1+) cations proceeds predominantly at an internal carbon to afford (pentenediyl)iron complexes. Those complexes bearing an electron withdrawing group at the σ-bound carbon (i.e., 13/14) are stable and isolable, while complexes which do not contain an electron withdrawing group at the σ-bound carbon undergo CO insertion, reductive elimination and conjugation of the double bond to afford cyclohexenone products (21/22). Deprotonation of the phosphonate 13/14 or 21 and reaction with paraformaldehyde affords the olefinated products. This methodology was utilized to prepare oxygenated carvone metabolites (±)-25 and (±)-26.
Conversion of alkyl halides into alcohols via formyloxylation reaction with DMF catalyzed by silver salts
Abad, Antonio,Agullo, Consuelo,Cunat, Ana C.,Navarro, Ismael
, p. 3355 - 3361 (2007/10/03)
The transformation of alkyl halides into alcohols via a two-step process based on the reaction with DMF catalyzed by Ag(I) salts followed by acid or basic hydrolysis of the intermediate formate ester has been evaluated. The results show that a large variety of primary and some secondary alkyl halides can be transformed efficiently into the corresponding alcohols, making this alkyl halide to alcohol interconversion a valuable alternative to the existing procedures, particularly in molecules with labile functional groups that are generally involved in multistep synthesis. Georg Thieme Verlag Stuttgart.
In vivo studies on the metabolism of the monoterpenes S-(+)- and R-(-)-carvone in humans using the metabolism of ingestion-correlated amounts (MICA) approach
Engel
, p. 4069 - 4075 (2007/10/03)
The major in vivo metabolites of S-(+)- and R-(-)-carvone in a metabolism of ingestion correlated amounts (MICA) experiment were newly identified as α,4-dimethyl-5-oxo-3-cyclohexene-1-acetic acid (dihydrocarvonic acid), α-methylene-4-methyl-5-oxo-3-cycloh
