362489-83-6Relevant academic research and scientific papers
Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Duan, James J.-W.,Chen, Lihua,Lu, Zhonghui,Xue, Chu-Biao,Liu, Rui-Qin,Covington, Maryanne B.,Qian, Mingxin,Wasserman, Zelda R.,Vaddi, Krishna,Christ, David D.,Trzaskos, James M.,Newton, Robert C.,Decicco, Carl P.
, p. 241 - 246 (2008/09/18)
β-Benzamido hydroxamic acids were discovered as potent TACE inhibitors. A computer model was constructed to help understanding the binding activities and guiding SAR study. SAR optimization led to the discovery of compound 30 which met all in vitro and in
