362669-86-1

Basic information

• Product Name: N-(2-Aminophenyl)-7-(2-naphthoyl)heptanamide
• Synonyms: N-(2-Aminophenyl)-7-(2-naphthoyl)heptanamide
• CAS NO: 362669-86-1
• Molecular Weight: 374.483
• Mol File: 362669-86-1.mol

Chemical Properties

• CAS DataBase Reference: N-(2-Aminophenyl)-7-(2-naphthoyl)heptanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Aminophenyl)-7-(2-naphthoyl)heptanamide(362669-86-1)
• EPA Substance Registry System: N-(2-Aminophenyl)-7-(2-naphthoyl)heptanamide(362669-86-1)

Safety Data

• Hazardous Substances Data: 362669-86-1(Hazardous Substances Data)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 362669-52-1 7-(2-naphthoyl)heptanoic acid 
• 362669-46-3 ethyl 7-(2-naphthoyl)heptanoate 
• 2243-83-6 2-naphthaloyl chloride 
• 51100-70-0 ethyl 7-iodoheptanoate 

Relevant articles and documents

(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors

A variety of ω-substituted alkanoic acid (2-amino-phenyl)-amides were designed and synthesized. These compounds were shown to inhibit recombinant human histone deacetylases (HDACs) with IC50 values in the low micromolar range and induce hyperacetylation of histones in whole cells. They induced expression of p21WAF1/Cip1 and caused cell-cycle arrest in human cancer cells. Compounds in this class showed efficacy in human tumor xenograft models.

Inhibitors of histone deacetylase

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.