362703-10-4Relevant articles and documents
Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Duan, James J.-W.,Chen, Lihua,Lu, Zhonghui,Xue, Chu-Biao,Liu, Rui-Qin,Covington, Maryanne B.,Qian, Mingxin,Wasserman, Zelda R.,Vaddi, Krishna,Christ, David D.,Trzaskos, James M.,Newton, Robert C.,Decicco, Carl P.
, p. 241 - 246 (2008/09/18)
β-Benzamido hydroxamic acids were discovered as potent TACE inhibitors. A computer model was constructed to help understanding the binding activities and guiding SAR study. SAR optimization led to the discovery of compound 30 which met all in vitro and in
SULPHONAMIDE DERIVATIVES AND THEIR USE AS TACE INHIBITORS
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Page 69-70, (2010/02/06)
Sulphonamide derivatives that are useful in the inhibition of metalloproteinases and in particular in the inhibition of TNF-α Converting Enzyme (TACE).