362703-48-8Relevant articles and documents
BICYCLIC TRIAZOLE A4 INTEGRIN INHIBITORS
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Page/Page column 38-39, (2008/06/13)
The compounds of the present invention are novel bicyclic triazole amino acid-derivatives useful as a4 integrin receptor antagonists. The invention is further directed to methods for treating integrin mediated disorders including, but not limited to, infl
The Baylis-Hillman reaction with chiral α-amino aldehydes under racemization-free conditions
Coelho, Fernando,Diaz, Gaspar,Abella, Carlos A. M.,Almeida, Wanda P.
, p. 435 - 439 (2007/10/03)
The Baylis-Hillman reaction with chiral α-amino aldehydes has been revisited. The reaction carried out under the influence of ultrasound avoids the aldehyde racemization almost completely, providing useful chiral substrates which can be used as starting materials for the synthesis of natural products. To demonstrate the synthetic applicability of these adducts, the easy preparation of a bicyclic lactam with an indolizidinic skeleton was accomplished. Georg Thieme Verlag Stuttgart.
Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha
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Page/Page column 48, (2010/11/30)
The present application describes novel β-amino acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor
Rowley, Michael,Collins, Ian,Broughton, Howard B.,Davey, William B.,Baker, Raymond,Emms, Frances,Marwood, Rosemarie,Patel, Shil,Patel, Smita,Ragan, C. Ian,Freedman, Stephen B.,Ball, Richard,Leeson, Paul D.
, p. 2374 - 2385 (2007/10/03)
5-(4-Chlorophenyl)-3-(1-(4-chlorobenzyl)piperidin-4-yl)pyrazole (3) was identified from screening of the Merck sample collection as a human dopamine D4 (hD4) receptor ligand with moderate affinity (61 nM) and 4-fold selectivity over human D2 (hD2) recepto