36289-08-4Relevant academic research and scientific papers
Regioselective single-step synthesis of 2-aminoimidazole derivatives
Li, Erfei,Lin, Yifan,Wu, Xin,Mao, Xi,Kang, Honglan,Wen, Yihang,Bai, Yihui,Wang, Xiaoxia,Lv, Xin
, (2019)
A convenient single-step strategy for the regioselective assembly of 2-aminoimidazole derivatives is herein described. Through a transition metal-free domino addition/cyclization process, the reactions of unsymmetrical carbodiimides with propargylic amines mediated by Cs2CO3 selectively afforded the corresponding polysubstituted 2-aminoimidazoles in moderate to good yields under very mild conditions. The regioselectivity was reversed in the presence of TEA at a higher temperature. The obtained 2-(o-iodoaryl)amino imidazoles could be easily converted to 2-(2-biphenyl)amino imidazole, 2-(o-alkynylphenyl)amino imidazole, benzoimidazo[1,2-a]imidazole and N-(imidazol-2-yl)indole derivatives.
