36289-13-1

Usage

Class

Organic compounds

Type

Phenylimidazoles

Structure

Aromatic heterocyclic compound with a unique benzimidazole ring structure

Usage

Mainly used in the pharmaceutical industry as a building block in the synthesis of various drugs

Properties

Exhibits potential pharmacological properties and serves as a useful tool for researchers in the development of new pharmaceuticals

Safety

Proper handling and storage procedures should be followed to ensure safety and prevent any potential hazards.

InChI:InChI=1/C17H15N3O/c21-11-10-19-16(13-6-2-1-3-7-13)12-20-15-9-5-4-8-14(15)18-17(19)20/h1-9,12,21H,10-11H2

Upstream product

• 154055-44-4 2-(2-hydroxyethylamino)-1-phenacylbenzimidazole 
• 1228647-51-5 1-(2-oxo-2-phenylethyl)benzimidazole-2-sulfonic acid 
• 141-43-5 ethanolamine 

Downstream Products

• 1241950-10-6 2-(2-bromoethylamino)-1-phenacylbenzimidazole hydrobromide 

Relevant academic research and scientific papers

1-Acylmethylbenzimidazole-2-sulfonic acids and their cyclization by N-nucleophiles

New preparation method was developed for derivatives of 1,4-dihydro-1,2,4-triazino[4,3-a]-, 2-aryl-1(9)H-, and 1-R-imidazo[1,2-a] benzimidazole underlain by newly synthesized 1-acylmethylbenzimidazole-2- sulfonic acids. The latter react with 2-aminoethanol affording along with the previously described compounds of the 1-(2-hydroxyethyl)imidazobenzimidazole series also compounds of formerly unknown polycyclic system, 2,3,11,12-tetrahydro-1,3-oxazolo[2,3-a]imidazo[1,2-a]benzimidazole.

Research in the field of imidazo[1,2-a]benzimidazole derivatives: XXVII. 1-acylmethyl-2-(ω-hydroxyalkylamino)-benzimidazoles and their transformation into derivatives of tricyclic systems

1-Acylmethyl-2-(ω-hydroxyalkylamino)benzimidazoles were synthesized and their behavior under various conditions was investigated: at the thermolysis without solvent, at heating in DMF or in 2-aminoethanol, hydrohalic acids, and acetic anhydride, in the presence of chlorinating agents (SOCl2, POCl3). Depending on the reaction conditions derivatives were obtained of 1H-imidazo[1,2-a]-benzimidazole, 9H-2,3-dihydroimidazo[1,2-a] benzimidazole, and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]-benzimidazole that were suitable synthons for the synthesis of functionally substituted derivatives of these tricyclic systems.