363152-46-9Relevant academic research and scientific papers
Diastereoselective Michael reactions of (1R)-(+)-camphor methyl ketone enolates with nitro olefins
Palomo, Claudio,Aizpurua, Jesús M,Oiarbide,García, Jesús M,González, Alberto,Odriozola,Linden, Anthony
, p. 4829 - 4831 (2007/10/03)
The reaction of the sodium enolate of the methyl ketone 2 with a range of nitro olefins proceeds readily to give the corresponding Michael adducts in good yields and diastereoselectivities. Subsequent oxidative cleavage of the acyloin moiety provides γ-nitroalkanoic acids along with (1R)-(+)-camphor, the chiral auxiliary of the process, which can be recovered and reused.
