363191-99-5Relevant academic research and scientific papers
2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists
Palucki, Brenda L.,Park, Min K.,Nargund, Ravi P.,Tang, Rui,MacNeil, Tanya,Weinberg, David H.,Vongs, Aurawan,Rosenblum, Charles I.,Doss, George A.,Miller, Randall R.,Stearns, Ralph A.,Peng, Qianping,Tamvakopoulos, Constantin,Van Der Ploeg, Lex H. T.,Patchett, Arthur A.
, p. 1993 - 1996 (2007/10/03)
We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. The 5- and 6-alkylated piperazine compounds exhibit low bioactivation potential as measured by covale
