363192-22-7

Usage

Molecular structure

A compound consisting of a piperidine ring, a carboxylic acid functional group, a cyclohexyl group, and a 4-formyl (aldehyde) group.

Ester derivative

The presence of a 1,1-dimethylethyl ester moiety indicates that 1-Piperidinecarboxylic acid, 4-cyclohexyl-4-formyl-, 1,1-dimethylethyl ester is an ester formed from the reaction of a carboxylic acid with an alcohol.

Tert-butyl group

The 1,1-dimethylethyl ester moiety suggests the presence of a tert-butyl group, which can provide stability to the molecule.

Potential applications

1-Piperidinecarboxylic acid, 4-cyclohexyl-4-formyl-, 1,1-dimethylethyl ester has potential applications in organic synthesis and pharmaceutical industries due to its functional groups that can participate in various chemical reactions.

Biological interactions

The presence of functional groups and structural resemblance to biologically relevant molecules suggests potential for medicinal chemistry applications and interactions with biological systems.

Structural features

The compound contains a five-membered nitrogen-containing piperidine ring and a six-membered cyclohexane ring, which may contribute to its chemical and biological properties.

Upstream product

• 312638-89-4 4-cyclohexyl-4-methanesulfonyloxymethylpiperidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 10462-00-7 4-cyclohexylpiperidine-4-carboxylic acid ethyl ester 
• 312638-87-2 4-cyclohexyl-4-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 363192-33-0 4-cyclohexyl-4-[(2-hydroxy-1,1-dimethyl-ethylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 363192-23-8 C₂₃H₄₂N₂O₃ 
• 363192-36-3 4-cyclohexyl-4-(2-methoxycarbonyl-vinyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 624732-92-9 4-(2-cyanovinyl)-4-cyclohexylpiperidine-1-carboxylic acid tert-butyl ester 
• 674791-77-6 C₂₁H₃₇NO₄ 
• 852323-83-2 1-BOC-4-cyclohexyl-4-[(1-hydroxy)isobutyl]piperidine 
• 852323-86-5 1-BOC-4-cyclohexyl-4-[(N-methoxy)iminyl]piperidine 

Relevant academic research and scientific papers

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

Melanocortin receptor ligands

The present invention relates to compounds which comprise a 4-substituted piperidine ring linked to a substituted or unsubstituted hydrocarbyl ring. The compounds, including all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: wherein preferably R is substituted aryl, W1 is a carbocyclic unit, and W2 is a heteroatom comprising unit.

PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders r

SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS

Certain novel 4-substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Melanocortin receptor ligands

The present invention relates to compounds which comprise a 4-substituted piperidine ring linked to a substituted or unsubstituted hydrocarbyl ring. The compounds, including all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: wherein preferably R is substituted aryl, W is a pendant unit having the formula: -L-Q L is a linking unit, Q is preferably a cyclic hydrocarbyl unit; W1 is preferably a carbocyclic unit and W2 is a heteroatom comprising unit.

Substituted piperidines as melanocortin-4 receptor agonists

Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction. Also provided are methods of treating sexual dysfunction with a compound that is a selective agonist of MC-4R over any other human melanocortin receptor.