36321-73-0

Basic information

• Product Name: 1,2-DIBROMO-3,4,5,6-TETRAMETHYLBENZENE
• Synonyms: 1,2-DIBROMO-3,4,5,6-TETRAMETHYLBENZENE;DIBROMOPREHNITENE;Benzene,1,2-dibroMo-3,4,5,6-tetraMethyl-;5,6-Dibromoprehnitene;5,6-Dibromo-1,2,3,4-tetramethylbenzene;1,2-Dibromotetramethylbenzene
• CAS NO: 36321-73-0
• Molecular Formula: C₁₀H₁₂Br₂
• Molecular Weight: 292.01
• Product Categories: API intermediates
• Mol File: 36321-73-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 204-205 °C
• Boiling Point: 324.1 °C at 760 mmHg
• Flash Point: 173.4 °C
• Appearance: /
• Density: 1.562 g/cm³
• Vapor Pressure: 0.000475mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 1,2-DIBROMO-3,4,5,6-TETRAMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIBROMO-3,4,5,6-TETRAMETHYLBENZENE(36321-73-0)
• EPA Substance Registry System: 1,2-DIBROMO-3,4,5,6-TETRAMETHYLBENZENE(36321-73-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 36321-73-0(Hazardous Substances Data)

Usage

General Description

1,2-Dibromo-3,4,5,6-tetramethylbenzene is a well-known organic compound that falls under the category of organobromides. This chemical composition signifies that it contains bromine atoms. Organobromides are daily used in various industries such as medicine, agriculture, and manufacturing due to their capability to react with a wide range of other substances. However, information about the specific applications or properties of 1,2-Dibromo-3,4,5,6-tetramethylbenzene is trivial, probably due to its synthetic complexity or insignificant use in the commercial space. As with all chemicals, it should be handled with appropriate safety measures to avoid harmful exposure or reactions.

InChI:InChI=1/C10H12Br2/c1-5-6(2)8(4)10(12)9(11)7(5)3/h1-4H3

Upstream product

• 40101-36-8 1-Bromo-2,3,4,5-tetramethylbenzene 
• 7664-93-9 sulfuric acid 
• 488-23-3 1,2,3,4-Tetramethylbenzene 

Downstream Products

• 144037-85-4 2-Benzyl-3,4,5,6-tetramethyl-benzonitrile 
• 144037-88-7 2-(3-Fluoro-benzyl)-3,4,5,6-tetramethyl-benzonitrile 
• 1070663-80-7 3,4,5,6-tetramethyl XPHOS 
• 3938-11-2 dihydroxyprehnitene 
• 782471-88-9 dimethoxyprehnitene 
• 857356-94-6 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl 
• 488-23-3 1,2,3,4-Tetramethylbenzene 
• 144037-92-3 2-(4-Methoxy-benzyl)-3,4,5,6-tetramethyl-benzonitrile 
• 76054-72-3 3,4,5,6-Tetramethyl-1,2-dehydrobenzol 
• 88687-05-2 3,4,5,6-tetrakis(bromomethyl)-1,2-dibromobenzene 
• 144061-58-5 Pyridin-2-yl-(2,3,4,5-tetramethyl-phenyl)-acetonitrile 
• 144061-44-9 2-(2-pyridylmethyl)-3,4,5,6-tetramethylbenzonitrile 
• 144037-94-5 2,3,4,5-Tetramethyl-6-(3,4,5-trimethoxy-benzyl)-benzonitrile 
• 144037-90-1 2-(2-Methoxy-benzyl)-3,4,5,6-tetramethyl-benzonitrile 

Relevant articles and documents

Significantly improved method for the pd-catalyzed coupling of phenols with aryl halides: Understanding ligand effects

(Chemical Equation Presented) A variety of diaryl ethers were synthesized by the Pd-catalyzed reaction of (hetero)-aryl halides and phenols. These reactions were achieved through the use of two new di-tert-butylphosphino biaryl ligands that overcome several limitations of previously described methods.

Pd catalyzed coupling of 1,2-dibromoarenes and anilines: Formation of N,N-diaryl-o-phenylenediamines

1,2-Dibromoarenes were coupled with aniline derivatives to yield N,N-diaryl-o-phenylenediamines in moderate to good yield using a palladium/phosphine or palladium/carbene catalyst system. Under similar conditions, 1,2,4,5-tetrabromobenzene was coupled with aniline derivatives to produce the corresponding tetrasubstituted derivatives which are oxidized on workup to yield azophenines. The sequential reaction of two different anilines with 1-chloro-2-iodobenzene afforded mixed N,N-diaryl-o-phenylenediamines.

Halogenation Using Quaternary Ammonium Polyhalides. XIV. Aromatic Bromination and Iodination of Arenes by Use of Benzyltrimethylammonium Polyhalides-Zinc Chloride System

The reaction of arenes with benzyltrimethylammonium tribromide or benzyltrimethylammonium dichloroiodate in acetic acid in the presence of ZnCl2 at room temperature or at 70 deg C gave brome- or iodo-substituted arenes in good yield, respectively.