36337-33-4

Usage

Structure

Contains a naphthalene ring with a nitro group at the 3 position, a phenyl group at the 4 position, an amino group at the 2 position, and a carbonitrile group at the 1 position

Potential applications

Medicinal chemistry and drug development

Unique structure

Makes it an interesting target for further research in organic chemistry

Upstream product

• 4354-73-8 2-(cyclohexylidene)malononitrile 
• 102-96-5 (2-nitroethenyl)benzene 
• 5153-67-3 nitrostyrene 

Relevant academic research and scientific papers

Basic ionic liquid as catalyst for the efficient and green synthesis of 2-amino-3-nitrobenzonitriles in ethanol

A basic ionic liquid, [BmIm]OH was used as catalyst in the cyclocondensation of various kinds of vinylmalononitriles with nitroolefins in ethanol at reflux. A series of 2-amino-3-nitrobenzonitriles were obtained in reasonable yields. The straightforward and green protocol was found to be fairly efficient, and the catalyst could be recycled and reused in subsequent reactions with consistent activity. The mechanism of the reaction was discussed.

Cu(OTf)2/Et3N-promoted cyclocondensation of activated α-methylene alkenes and nitroolefins: a novel one-pot synthesis of polysubstituted benzenes

A simple and efficient one-pot synthesis of polyfunctionalized benzenes has been developed via cyclocondensation of activated α-methylene alkenes such as vinyl malononitriles and ethyl vinyl cyanoacetates with nitroolefins using Cu(OTf)2/Etsub

Efficient method for the synthesis of polysubstituted benzenes by one-pot tandem reaction of vinyl malononitriles with nitroolefins

(Chemical Equation Presented) The one-pot synthesis of polysubstituted benzene derivatives was achieved via vinylogous Michael addition of vinyl malononitriles and nitroolefins as the key step and a sequential tandem reaction. A series of complex aryl com