36342-07-1

Basic information

• Product Name: N-N-PROPYLMALEAMIC ACID, 98
• Synonyms: N-N-PROPYLMALEAMIC ACID, 98;4-oxo-4-(propylamino)isocrotonic acid;(Z)-4-Oxo-4-(propylamino)-2-butenoic acid;N-n-Propylmaleamidic acid
• CAS NO: 36342-07-1
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.16714
• EINECS: 252-986-9
• Mol File: 36342-07-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 376.4 °C at 760 mmHg
• Flash Point: 181.5 °C
• Appearance: /
• Density: 1.136 g/cm³
• Vapor Pressure: 1.05E-06mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: N-N-PROPYLMALEAMIC ACID, 98(CAS DataBase Reference)
• NIST Chemistry Reference: N-N-PROPYLMALEAMIC ACID, 98(36342-07-1)
• EPA Substance Registry System: N-N-PROPYLMALEAMIC ACID, 98(36342-07-1)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• Hazardous Substances Data: 36342-07-1(Hazardous Substances Data)

Usage

Uses

N-Propyl Maleamic Acid is a useful research reagent for organic synthesis and other chemical processes.

InChI:InChI=1/C7H11NO3/c1-2-5-8-6(9)3-4-7(10)11/h3-4H,2,5H2,1H3,(H,8,9)(H,10,11)/b4-3+

Upstream product

• 108-31-6 maleic anhydride 
• 107-10-8 propylamine 

Downstream Products

• 675876-25-2 but-2-enedioic acid benzyl-{benzylcarbamoyl-[1-(2-nitro-benzenesulfonyl)-1H-pyrrol-2-yl]-methyl}-amide propylamide 
• 21746-40-7 propylmaleimide 

Relevant articles and documents

Synthesis and antimicrobial activities of N-substituted imides

In the field of our research programs concerning novel antimicrobial agents, a series of N-substituted imides was synthesized. These compounds were obtained by cyclization of amido-acids in acetic anhydride/sodium acetate or hexamethyldisilazane/zinc bromide for the hydroxy-aromatic derivatives. The hydroxy-alkyl maleimides were directly prepared by condensation of the corresponding amino-alcohol with maleic anhydride in boiling toluene. Most of N-substituted maleimides showed an interesting antimicrobial activity towards bacteria from the ATCC collection (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) but the MIC values for P. aeruginosa were always high (128 μg/ml). The imides with alkyl substituents showed higher activities than aromatic analogues with MIC values in the range of 8-32 μg/ml. Comparatively, succinimides were practically inactive.