36342-07-1

Usage

Uses

Used in Research and Development:
N-N-PROPYLMALEAMIC ACID, 98 is used as a research reagent for organic synthesis and other chemical processes. Its unique chemical properties make it a valuable tool for scientists and researchers in the development of new compounds and materials.
Used in Pharmaceutical Industry:
N-N-PROPYLMALEAMIC ACID, 98 is used as an intermediate in the synthesis of various pharmaceutical compounds. Its versatility in chemical reactions allows for the creation of a wide range of drug candidates with potential therapeutic applications.
Used in Chemical Synthesis:
N-N-PROPYLMALEAMIC ACID, 98 is used as a building block in the synthesis of various organic compounds. Its reactivity and functional groups make it a useful component in the development of new molecules with specific properties and applications.
Used in Material Science:
N-N-PROPYLMALEAMIC ACID, 98 can be used as a component in the development of new materials with unique properties. Its chemical structure allows for the creation of materials with specific characteristics, such as improved strength, flexibility, or chemical resistance.

InChI:InChI=1/C7H11NO3/c1-2-5-8-6(9)3-4-7(10)11/h3-4H,2,5H2,1H3,(H,8,9)(H,10,11)/b4-3+

Upstream product

• 108-31-6 maleic anhydride 
• 107-10-8 propylamine 

Downstream Products

• 21746-40-7 propylmaleimide 
• 675876-25-2 but-2-enedioic acid benzyl-{benzylcarbamoyl-[1-(2-nitro-benzenesulfonyl)-1H-pyrrol-2-yl]-methyl}-amide propylamide 

Relevant academic research and scientific papers

Synthesis and antimicrobial activities of N-substituted imides

In the field of our research programs concerning novel antimicrobial agents, a series of N-substituted imides was synthesized. These compounds were obtained by cyclization of amido-acids in acetic anhydride/sodium acetate or hexamethyldisilazane/zinc bromide for the hydroxy-aromatic derivatives. The hydroxy-alkyl maleimides were directly prepared by condensation of the corresponding amino-alcohol with maleic anhydride in boiling toluene. Most of N-substituted maleimides showed an interesting antimicrobial activity towards bacteria from the ATCC collection (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) but the MIC values for P. aeruginosa were always high (128 μg/ml). The imides with alkyl substituents showed higher activities than aromatic analogues with MIC values in the range of 8-32 μg/ml. Comparatively, succinimides were practically inactive.

Antitumor chemotherapy. XIV. Cytotoxic activity of compounds possessing an ethylenic double bond substituted at the α and β positions with an electron attracting group

The authors have previously shown that molecules possessing an ethylene double bond, activated by one or 2 electron attracting substituents, show a cytotoxic activity which must be connected with the addition of a cellular nucleophil to their double bond. This correlation has been extended to N alkylmaleinimides and different compounds with paraquinonine structure. The compounds examined possess a distinct cytotoxic antitumor activity which is, however, inferior to that of α nitro stilbenes and β nitro styrenes, the simplified analogs of aristolochic acid.