36360-17-5Relevant academic research and scientific papers
EFFECT OF THE STRUCTURE ON THE RATE OF THE REACTIONS OF AROYL CHLORIDES WITH PRIMARY ARYLAMINES IN MIXTURES OF tert-BUTYL ALCOHOL AND CHLOROBENZENES. THE TRANSITION THROUGH ISOPARAMETRIC POINTS WITH RESPECT TO THE STRUCTURE PARAMETERS
Shpan'ko, I. V.,Likhomanenko, E. E.
, p. 1702 - 1710 (2007/10/02)
The rate of the reactions of aroyl chlorides with primary arylamines in 3.5, 5, and 7M solutions of tert-butyl alcohol in chlorobenzene at 25 deg C was measured.The effect of the structure of the reagents on the process rate was determined quantitatively by means of the Hammett-Taft and crossed correlation equations.The isoparametric points with respect to the structure of the substrate and the nucleophile were reached experimentally, and the transition through some of these points was also realised.It was found that the specific solvation of the primary arylamines by the tert-butyl alcohol was nonuniform in that an incre ase in the concentration of the alcohol in the investigated range reduced, did not change, and increased the rates of the reactions with 3-chloroaniline, 3-nitroaniline, and 3-nitro-5-methoxycarbonylaniline respectively.The effect of specific solvation on the behavior of the correlation parameters is discussed.
MUTUAL EFFECT OF THE STRUCTURES OF THE REAGENTS ON THE RATE OF THE REACTIONS OF AROYL CHLORIDES WITH PRIMARY ARYLAMINES IN DIOXANE AND MIXTURES OF CHLOROBENZENE WITH tert-BUTYL ALCOHOL
Likhomanenko, E. E.,Shpan'ko, I. V.,Litvinenko, L. M.,Goncharov, A. N.
, p. 2341 - 2347 (2007/10/02)
The rate of the reactions of aroyl chlorides with primary arylamines in specifically solvating media (dioxane, 0.1 M and 2 M solutions of tert-butyl alcohol in chlorobenzene) was measured.The joint effect of the structures of the reagents on the rate of the process in the employed media assessed quantitatively by crossed correlation.It was shown that the mutual effect of the structural factors on the reactivity is nonadditive in a 0.1 M solution of tert-butyl alcohol in chlorobenzene and additive in dioxane and also in a 2 M solution of tert-butyl alcohol in chlorobenzene.The effect of the structure of the reagents and specific solvation on the nature of the transition states of the reactions is discussed.
JOINT EFFECT OF THE STRUCTURE OF THE REAGENTS AND THE POLARITY OF THE MEDIUM ON THE RATE OF REACTIONS OF AROYL CHLORIDES WITH PRIMARY ARYLAMINES. CROSSED CORRELATION
Shpan'ko, I. V.,Likhomanenko, E. E.,Litvinenko, L. M.,Goncharov, A. N.
, p. 1390 - 1397 (2007/10/02)
The kinetics of the reactions of aroyl chlorides with primary arylamines in volume mixtures of chlorobenzene with nitrobenzene were studied with crossed variation in the structures of the reagents.The effect of various factors (the structure of the primary arylamines, the structure of the aroyl chlorides, the polarity of the medium), varied separately and in pairs, and also the joint effect of the three factors on the process rate were assessed.It was found that the structure of the reagents and the polarity of the medium have a nonadditive type of mutual effect on the reactivity of the aroyl chloride-primary arylamine system.The influence of the varied factors on the nature of the transition states in the reactions is discussed.
Anti-allergic oxanilate compounds
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, (2008/06/13)
A method of treating mammals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature which comprises administering prophylactically to said mammal an anti-allergy or anaphylactic reaction effective amount of a compound of the formula STR1 Novel compounds and compositions are also claimed.
