Tlr2-IN-C29 is a compound that functions as an inhibitor of TLR2/1 and TLR2/6 signaling pathways. It is effective in inhibiting these signaling pathways when induced by both synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells. However, its inhibitory action is limited to TLR2/1 signaling in murine macrophages.
363600-92-4
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Basic information
- Product Name: TLR2-IN-C29
- Synonyms: TLR2-IN-C29
- CAS NO:363600-92-4
- Molecular Formula: C16H15NO4
- Molecular Weight: 285.2946
- EINECS: -0
- Product Categories: N/A
- Mol File: 363600-92-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 505.7±50.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.21±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
- Solubility: DMSO (Slightly), Methanol (Slightly)
- PKA: 4.01±0.10(Predicted)
- Stability: Moisture Sensitive
- CAS DataBase Reference: TLR2-IN-C29(CAS DataBase Reference)
- NIST Chemistry Reference: TLR2-IN-C29(363600-92-4)
- EPA Substance Registry System: TLR2-IN-C29(363600-92-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 363600-92-4(Hazardous Substances Data)
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363600-92-4 Usage
Uses
Used in Pharmaceutical Industry:Tlr2-IN-C29 is used as a research compound for studying the role of TLR2/1 and TLR2/6 signaling pathways in various diseases and conditions. Its ability to inhibit these pathways makes it a valuable tool in understanding the underlying mechanisms of immune responses and inflammation.
Used in Immunology Research:
Tlr2-IN-C29 is used as an inhibitor in immunological research to investigate the specific functions of TLR2/1 and TLR2/6 signaling pathways. This can help in identifying potential therapeutic targets for the treatment of autoimmune diseases, inflammatory conditions, and other disorders related to the immune system.
Used in Drug Development:
Tlr2-IN-C29 can be utilized in the development of new drugs targeting TLR2/1 and TLR2/6 signaling pathways. By inhibiting these pathways, it may be possible to develop treatments for conditions where these pathways are overactive or dysregulated, such as chronic inflammation or autoimmune diseases.
Used in Cell Line Studies:
Tlr2-IN-C29 is used in cell line studies involving human HEK-TLR2 and THP-1 cells, as well as murine macrophages, to evaluate the effects of TLR2/1 and TLR2/6 signaling inhibition on cellular responses and functions. This can provide insights into the potential therapeutic applications of Tlr2-IN-C29 in various disease models.
Check Digit Verification of cas no
The CAS Registry Mumber 363600-92-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,3,6,0 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.Calculate Digit Verification of CAS Registry Number 363600-92:
(8*3)+(7*6)+(6*3)+(5*6)+(4*0)+(3*0)+(2*9)+(1*2)=134
134 % 10 = 4
So 363600-92-4 is a valid CAS Registry Number.
363600-92-4Upstream product
363600-92-4Downstream Products
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TLR2-IN-C29
