363607-77-6Relevant academic research and scientific papers
Synthesis of (±)Abyssinone I and related compounds: Their anti-oxidant and cytotoxic activities
Rao, Gudapati Venkateswara,Swamy, Badrappa Narayana,Chandregowda, Venkateshappa,Reddy, G. Chandrasekara
experimental part, p. 2239 - 2245 (2009/09/08)
An efficient and facile synthesis of naturally occurring prenylated flavonoids and their analogs have been described. Abyssinone I (9a) was prepared by condensing 2,2-dimethyl chrom-3-en-6-carboxaldehyde (5a) with protected resacetophenone under phase transfer conditions followed by deprotection and cyclization. The influence of prenyl group on anti-oxidant and cytotoxic activities was studied. The presence of 3′-prenyl group as in 8c enhanced radical scavenging activity but decreased reducing power activity when compared to non-prenylated analog 8f. In vitro testing in MCF-7 cell line revealed that prenylated chalcones and flavanones showed better inhibitory activity than their non-prenylated counterparts. Abyssinone I and its chalcone though exhibited negligible anti-oxidant activity their cytotoxic activities were comparable with other prenylated analogs.
CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF
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Page/Page column 22; 35-36, (2008/12/06)
Substituted flavonoid compounds, and pharmaceutical formulations of flavonoid compounds are described. Also described are processes for preparing flavonid compounds, as are methods for treating cancer in mammals using the described flavonoid compounds or pharmaceutical formulations thereof.
