36361-64-5

Upstream product

• 92-92-2 biphenyl-4-carboxylic acid 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 18622-23-6 4-phenylbenzohydrazide 
• 322669-22-7 N'-acetyl-biphenyl-4-carboxylic hydrazide 
• 62778-17-0 5-([1,1′-biphenyl]-4-yl)-2H-tetrazole 
• 108-24-7 acetic anhydride 

Downstream Products

• 374888-02-5 3-(biphenyl-4-yl)-5-methyl-4-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazole 
• 374889-49-3 3-(biphenyl-4-yl)-4-(4-fluorophenyl)-5-methyl-4H-1,2,4-triazole 
• 313502-52-2 3-(biphenyl-4-yl)-5-methyl-4-(2-methylphenyl)-4H-1,2,4-triazole 
• 374889-61-9 3-(biphenyl-4-yl)-5-methyl-4-(2-propylphenyl)-4H-1,2,4-triazole 
• 258878-26-1 3-(biphenyl-4-yl)-4-(2-isopropylphenyl)-5-methyl-4H-1,2,4-triazole 
• 1260172-88-0 3-(biphenyl-4-yl)-4-(2-chlorophenyl)-5-methyl-4H-1,2,4-triazole 
• 313367-48-5 3-(biphenyl-4-yl)-5-methyl-4-phenyl-4H-1,2,4-triazole 
• 1260172-87-9 3-(biphenyl-4-yl)-4-isopropyl-5-methyl-4H-1,2,4-triazole 
• 1260172-86-8 3-(biphenyl-4-yl)-4-cyclohexyl-5-methyl-4H-1,2,4-triazole 
• 374889-60-8 3-(biphenyl-4-yl)-4-(2-ethylphenyl)-5-methyl-4H-1,2,4-triazole 
• 374889-38-0 3-(biphenyl-4-yl)-4-(2-fluorophenyl)-5-methyl-4H-1,2,4-triazole 
• 374889-64-2 3-(biphenyl-4-yl)-4-(3-fluorophenyl)-5-methyl-4H-1,2,4-triazole 

Relevant academic research and scientific papers

Synthesis and spectral properties of 2-methyl-5-aryl-1,3,4-oxadiazoles

By heterocyclization of 1-acyl-2-aroylhydrazines under the influence of strong dehydrating substances, a series of 2-methyl-5-aryl-1,3,4-oxadiazoles has been synthesized and their UV, IR, and PMR spectra have been investigated. Through analysis of data on

Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4 h -1,2,4-triazoles as novel glycine transporter 1 inhibitors

We describe the preparation and evaluation of a novel series of glycine transporter 1 (GlyT1) inhibitors derived from a high-throughput screening hit. The SAR studies resulted in the discovery of 3-biphenyl-4-yl-4-(2-fluorophenyl)- 5-isopropyl-4H-1,2,4-tr

Discovery of 4,5-diphenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human V(1A) receptor.

In the search for a novel class of selective antagonists for the human V(1A) receptor, high-throughput screening (HTS) of the Yamanouchi chemical library using CHO cells expressing the cloned human V(1A) (hV(1A)) receptor led to the discovery of 5-(4-biphenyl)-4-(2-methoxyphenyl)-3-methyl-1,2,4-triazole (3) which possessed the novel 4,5-diphenyl-1,2,4-triazole structure. Subsequent structure-activity relationships studies on a series of the 4,5-diphenyl-1,2,4-triazole derivatives related to 3 revealed that the 4,5-diphenyl-1,2,4-triazole structure played an essential role in exerting high affinity for the hV(1A) receptor and that introduction of a basic amine moiety to the methoxy part of the 4-phenyl ring was effective in the improvement of both affinity for the hV(1A) receptor and selectivity versus the hV(2) receptor. Compound 3 and the 2-(morphorino)ethoxy derivative (11b) were shown to be antagonists for the hV(1A) receptor, from their effects on AVP-induced [Ca(2+)](i) response in CHO cells expressing the hV(1A) receptor.