36367-85-8

Basic information

• Product Name: 3-Cyclopenten-1-ol, 4-methylbenzenesulfonate
• CAS NO: 36367-85-8
• Molecular Formula: C12H14O3S
• Molecular Weight: 238.307
• Mol File: 36367-85-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 3-Cyclopenten-1-ol, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclopenten-1-ol, 4-methylbenzenesulfonate(36367-85-8)
• EPA Substance Registry System: 3-Cyclopenten-1-ol, 4-methylbenzenesulfonate(36367-85-8)

Safety Data

• Hazardous Substances Data: 36367-85-8(Hazardous Substances Data)

Usage

General Description

3-Cyclopenten-1-ol, 4-methylbenzenesulfonate is a chemical compound consisting of a cyclopentenol molecule attached to a 4-methylbenzenesulfonate group. It is commonly used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. The compound is known for its ability to undergo nucleophilic substitution reactions, making it a valuable building block in the creation of various organic compounds. Its unique structure and reactivity make it a versatile tool in the field of organic chemistry, with potential applications in drug discovery and development.

Upstream product

• 14320-38-8 cyclopent-3-enol 
• 98-59-9 p-toluenesulfonyl chloride 
• 7129-41-1 6-oxabicyclo[3.1.0]hex-2-ene 
• 542-92-7 cyclopenta-1,3-diene 
• 2883-45-6 1, 6-heptadien-4-ol 
• 58794-15-3 hepta-1,6-dien-4-yl 4-methylbenzenesulfonate 

Downstream Products

• 474087-23-5 (+/-)-(1R,5S,7r)-7-(3-benzyloxy-3-oxido-2,4-dioxa-3-phospha-bicyclo[3.3.0]octyl)-2H-1-benzopyran-2-one 
• 766-00-7 2-cyclopentyl-ethanol 
• 1258451-51-2 1-Chloro-2-(cyclopent-3-enylsulfanyl)-benzene 
• 3467-69-4 cyclopent-3-enyl phenyl thioether 

Relevant articles and documents

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme

Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of l-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncology. We developed a class of inhi

COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN DIOXYGENASE

The present invention relates to bicyclic compounds and compositions and methods which may be useful as inhibitors of IDO1, IDO2, and TDO for the treatment or prevention of diseases such as cancer.

4-Aminocyclopentane-1,3-diols as platforms for diversity: Synthesis of a screening library

Trisubstituted cyclopentanes have a discrete shapely curvature. While the central ring of these compounds is devoid of rotatable bonds, the pseudo rotation of the cyclopentane ring leads to a desirable disruption of planarity. This is favorable for aqueous solubility and enables addressing of wide-ranging conformational space. The sp3-rich framework of 4-aminocyclopentane- 1,3-diols offers stereochemically defined attachment points for substituents and renders these fragment-like molecules good platforms for molecular diversity. By using an established N-selective polymer-assisted acylation protocol, these scaffolds with natural product-like properties were transformed into a screening library by attachment of substituents at defined positions. Here we describe the synthesis and characterization of these molecular platforms and their use as starting points for the construction of an 80-member library of 4-amidocyclopentane-1,3-diol monoethers. Five of the compounds displayed cytotoxicity in a tumor cell line assay with IC50 values in the low micromolar range.