36371-18-3Relevant academic research and scientific papers
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents
Catalano, Alessia,Carocci, Alessia,Corbo, Filomena,Franchini, Carlo,Muraglia, Marilena,Scilimati, Antonio,De Bellis, Michela,De Luca, Annamaria,Camerino, Diana Conte,Sinicropi, Maria Stefania,Tortorella, Vincenzo
, p. 2535 - 2540 (2008/12/23)
1-Benzyl-N-(2,6-dimethylphenyl)piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide, two conformationally restricted analogues of tocainide, were designed and synthesized as voltage-gated skeletal muscle sodium channel blockers. They showed, with respect to tocainide, a marked increase in both potency and use-dependent block.
