36377-88-5Relevant academic research and scientific papers
Highly stereoselective chlorination of β-substituted cyclic alcohols using PPh3-NCS: Factors that control the stereoselectivity
Jaseer,Naidu, Ajay B.,Kumar, Sreehari S.,Rao, R. Koteshwar,Thakur, Krishna G.,Sekar
, p. 867 - 869 (2007)
A variety of trans-β-substituted cyclic alcohols were stereoselectively chlorinated to either the corresponding cis-chloride or trans-chloride (inversion or retention of configuration) with good to excellent yields; the stereochemical outcome is determined by the size of the ring and the nature of the β-substituents, especially the electronegativity of the substituted atom. The Royal Society of Chemistry.
