364-53-4 Usage
Uses
Used in Organic Synthesis:
3,4-Dinitrofluorobenzene is used as a reagent in organic synthesis for the modification of proteins and peptides. Its strong electrophilic nature allows for the derivatization of amino groups, which is crucial for various immunoassays and analytical techniques in the field of biochemistry and molecular biology.
Used in Research on Allergic Contact Dermatitis:
In the field of immunology and dermatology, 3,4-dinitrofluorobenzene serves as a skin sensitizer and is utilized in research to study the mechanisms of allergic contact dermatitis. This application aids in understanding the immune system's response to allergens and contributes to the development of treatments for skin allergies.
Used in Analytical Techniques:
3,4-Dinitrofluorobenzene is employed as a derivatizing agent in analytical techniques to enhance the detection and analysis of specific compounds. Its ability to react with amino groups makes it a useful tool in improving the sensitivity and specificity of certain assays.
Safety Considerations:
Due to its reactivity and potential health hazards, it is essential to handle 3,4-dinitrofluorobenzene with caution. Proper safety measures, including the use of personal protective equipment and adherence to laboratory safety protocols, are crucial when working with 3,4-DINITROFLUOROBENZENE to minimize risks of exposure and adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 364-53-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 364-53:
(5*3)+(4*6)+(3*4)+(2*5)+(1*3)=64
64 % 10 = 4
So 364-53-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H3FN2O4/c7-4-1-2-5(8(10)11)6(3-4)9(12)13/h1-3H
364-53-4Relevant academic research and scientific papers
Regioselective synthesis of 4-halo ortho-dinitrobenzene derivatives
Mundla, Sreenivasa R.
, p. 4277 - 4279 (2007/10/03)
A novel method for the regioselective synthesis of 4-halo ortho- dinitrobenzene derivatives was developed by reacting various meta-halo nitrobenzenes with urea nitrate in concentrated sulfuric acid. (C) 2000 Elsevier Science Ltd.
Competitive Cyclisations of Singlet and Triplet Nitrenes. Part 8. The 1-(2-Nitrenophenyl)pyrazoles and Related Systems
Lindley, John M.,McRobbie, Ian M.,Meth-Cohn, Otto,Suschitzky, Hans
, p. 982 - 994 (2007/10/02)
The title nitrenes, derived by nitro-group deoxygenation with triethyl phosphite or by thermolysis or photolysis of the corresponding azide, have been studied.The effect of substituents (Cl, Br, OMe, NMe2, Me, CF3, and NO2) both meta and para to the nitrene has been examined as a determinant of the preferred mode of cyclisation to either a pyrazolobenzotriazole or a pyrazoloquinoxaline.Similarly, the role of solvents, sensitisers, and quenchers has been studied.Routes to the isomeric 1- and 2-(2-nitrophenyl)-4,5,6,7-tetrahydroindazoles have been defined and the literature corrected by studing the nitrene-mediated cyclisation of these products.The chemistry of the analogous 1-(2-carbenophenyl)- and the 1-(2-nitrenosulphonylphenyl)-3,5-dimethylpyrazoles has also been examined, the former giving 2-(3,5-dimethylpyrazol-1-yl)-benzaldazine and -benzyl alcohol while the latter gave products of intramolecular nitrene attack (a pyrazolobenzothiatriazine) and intermolecular reaction.Rationalisations for all the reaction pathways have been advanced.
