364039-53-2

Upstream product

• 364039-62-3 7-methoxy-4-oxo-2-(3,4,5-trimethoxy-phenyl)-chroman-3-carboxylic acid ethyl ester 
• 364039-43-0 7-methoxy-2-(3,4,5-trimethoxy-phenyl)-2H-chromene-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Novel chromene derivatives as TNF-α inhibitors

A novel series of chromene-based TNF-α inhibitors is described. These chromene derivatives inhibit bacterial lipopolysaccharide (LPS) stimulated production of TNF-α from human peripheral blood mononuclear cells (PBMC). Additionally, these compounds inhibit NF-kB mediated transcription activation.