364041-47-4

Upstream product

• 60-18-4 L-tyrosine 
• 29588-94-1 N-phthaloyl-L-tyrosine 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 39739-09-8 methyl (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(4-hydroxyphenyl)propanoate 

Downstream Products

• 364041-52-1 C₂₅H₂₂BNO₇ 
• 364041-50-9 (S)-3-[4-Benzyloxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of the biaryl moiety of the proteasome inhibitors TMC-95 via a ligandless Pd(OAc)2-catalyzed Suzuki-coupling reaction

The biaryl moiety of proteasome inhibitors TMC-95 was synthesized via a Pd(OAc)2-catalyzed Suzuki-coupling reaction of 7-iodoisatin and a tyrosine-derived arylboronic acid in the absence of phosphine ligands using potassium fluoride as a base.