364050-21-5

Basic information

• Product Name: 1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)-
• Synonyms: 1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)-;1-(6-Methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione
• CAS NO: 364050-21-5
• Molecular Formula: C₁₆H₁₁N₃O₂
• Molecular Weight: 277.27744
• Mol File: 364050-21-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 123-124 °C
• Boiling Point: 496.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.317±0.06 g/cm3(Predicted)
• PKA: 1.13±0.10(Predicted)
• CAS DataBase Reference: 1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)-(364050-21-5)
• EPA Substance Registry System: 1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)-(364050-21-5)

Safety Data

• Hazardous Substances Data: 364050-21-5(Hazardous Substances Data)

Usage

General Description

1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)- is a chemical compound that contains a backbone of ethanedione with two attached heterocyclic rings - one being 6-methyl-2-pyridinyl and the other being 6-quinoxalinyl. 1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)- is a diketone derivative with potential applications in organic synthesis and medicinal chemistry. It can be used as a building block in the synthesis of various pharmaceuticals and biologically active compounds. Additionally, the presence of heterocyclic rings in its structure may impart specific biological activities, making it of interest for further research and development in the field of pharmaceuticals and medicinal chemistry.

Upstream product

• 356560-90-2 2-(6-methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone 
• 258503-93-4 quinoxaline-6-carbonyl chloride 
• 108-48-5 2,6-dimethylpyridine 

Downstream Products

• 442517-38-6 2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazole 
• 1145871-52-8 6-[2-benzyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline 
• 1145871-58-4 6-[5-(6-methylpyridin-2-yl)-2-phenethyl-1H-imidazol-4-yl]quinoxaline 
• 364050-20-4 6-[2-(4-Cyanophenyl)-5-(6-methylpyridin-2-yl)-1H-imidazole-4-yl]-quinoxaline 

Relevant articles and documents

Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles (15a-l) have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 4-[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]b enzenesulfonamide (15b) and 4-[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]be nzenesulfonamide (15c) showed more than 90% inhibition at 0.5 μM in a luciferase reporter assay using HaCaT cells transiently transfected with p3TP-luc reporter construct, but inhibited p38α MAP kinase activity only 11 and 8% at a concentration of 10 μM, respectively.

2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors

Compounds of the formula: wherein R1, R2, R3, A1 and A2 are as defined herein, which are used advantageously in inhibiting the TGF-β and/or activin signaling pathway in mammals.