3641-10-9

Usage

Uses

Used in Pharmaceutical Research:
3-Cyano-1,2,4-triazole is used as a research compound for studying the electrophilicity and reactivity of diverse nitrile-containing compounds. Its correlation to the mechanism-of-action is of particular interest, as understanding these properties can lead to the development of new therapeutic agents.
Used in Enzyme Inhibition Studies:
In the field of biochemistry, 3-Cyano-1,2,4-triazole is utilized as an inhibitor of cathepsin K, providing insights into the enzyme's role in various biological processes. This application aids in the exploration of potential treatments for conditions related to bone metabolism and immune system function.
Used in Material Science:
3-Cyano-1,2,4-triazole's reactivity and electrophilicity also make it a candidate for use in material science research. Its properties can be harnessed to develop new materials with specific characteristics, such as enhanced stability or reactivity, for various industrial applications.

InChI:InChI=1/C3H2N4/c4-1-3-5-2-6-7-3/h2H,(H,5,6,7)

Upstream product

• 6818-99-1 3-chloro-1H-1,2,4-triazole 
• 773837-37-9 sodium cyanide 
• 54606-55-2 cyanoformimidic acid hydrazide 
• 122-51-0 orthoformic acid triethyl ester 
• 3641-08-5 1,2,4-triazole-3-carboxamide 

Downstream Products

• 1571215-37-6 4-(2-bromo-4-fluorophenyl)-2-(3-cyano-1,2,4-triazol-1-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 1446756-76-8 C₁₄H₁₆N₁₀ 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 123147-83-1 1-β-D-ribofuranosyl<1,2,4>triazole-3-carbonitrile 
• 68-94-0 hypoxanthine 
• 4928-87-4 3-carboxylic acid-4H-1,2,4-triazole 

Relevant academic research and scientific papers

Isosteric ribavirin analogues: Synthesis and antiviral activities

The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.

Chemoenzymatic method of 1,2,4-triazole nucleoside synthesis: Possibilities and limitations

Possibilities and limitations of chemoenzymatic synthesis of novel structural analogues of an antiviral preparation of Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were established. A synthesis of various amides of 1H-1,2,4-triazole-3-carboxylic acid and its 5-substituted analogues - potential substrates of purine nucleoside phosphorylase - has been described. Comparative efficiency of preparation methods of these amides, as well as the methods of introduction of functional groups to the C5 position of heterocyclic system, were investigated. Novel analogues of Ribavirin containing various substitutes in the carboxamide group were synthesized. A biotechnological method was developed for the preparation of 1-β-D-ribofuranozyl-1,2,4-triazole-3-carbonitryl, an intermediate in the synthesis of Viramidine, the modern analogue of Ribavirin.

PROCESS FOR THE PREPARATION OF CYANO-SUBSTITUTED-NITROGEN-CONTAINING HETEROARYL COMPOUNDS

The present invention provides compounds and methods that can be used to convert nitrogen-containing-heteroaryl carboxamides to the corresponding nitrogen-containing-heteroaryl nitriles reliably in one step, with high yields and without the need for elaborate purification.