36432-31-2Relevant articles and documents
Effect of methyl groups onto imidazolium cation ring on liquid crystallinity and ionic conductivity of amphiphilic ionic liquids
Mukai, Tomohiro,Yoshio, Masafumi,Kato, Takashi,Ohno, Hiroyuki
, p. 1630 - 1631 (2004)
Phase transition behavior of imidazolium dodecylsulfonate was considerably affected by the introduction of methyl groups onto the imidazolium cation ring. Methyl group on the 2-position eliminated the liquid crystallinity. That on the 4-position was effective to suppress the crystallization. Copyright
Twisted Push-Pull Alkenes Bearing Geminal Cyclicdiamino and Difluoroaryl Substituents
Kundu, Abhinanda,Chandra, Shubhadeep,Mandal, Debdeep,Neuman, Nicolás I.,Mahata, Alok,Anga, Srinivas,Rawat, Hemant,Pal, Sudip,Schulzke, Carola,Sarkar, Biprajit,Chandrasekhar, Vadapalli,Jana, Anukul
, p. 12683 - 12692 (2021/09/18)
The systematic combination of N-heterocyclic olefins (NHOs) with fluoroarenes resulted in twisted push-pull alkenes. These alkenes carry electron-donating cyclicdiamino substituents and two electron-withdrawing fluoroaryl substituents in the geminal posit
Synthesis of new hetero-arylidene-9(10H)-anthrone derivatives and their biological evaluation
Baptista, Pedro V.,Branco, Paula S.,Fernandes, Alexandra R.,Malta, Gabriela,Peixoto, Daniela,Roma-Rodrigues, Catarina,Ferreira, Luísa M.
, (2020/04/22)
New hetero-arylidene-9(10H)-anthrone derivatives (1) were synthesized from reaction of 1,2-dimethyl-3-alkyl imidazolium salts (2) and 9-anthracenecarboxaldehyde. Ion exchange of the anion with dioctyl sulfosuccinate and lithium bis(trifluoromethanesulfonyl)imide led to the preparation of other derivatives. The antiproliferative effect of the compounds was evaluated in human ovarian (A2780) and colorectal (HCT116) carcinoma cell lines and in normal primary human fibroblasts. Compound 1 presented an antiproliferative effect related to the imidazolium pattern of substitution with compounds having a decyl group at the R-position (1c and 3c) showing the highest cytotoxic activities in all cell lines independently of the counter ion. Compounds 1b and 1c internalize A2780 cancer cells via a passive or an active transport, respectively, inducing A2780 cell death via an extrinsic apoptosis (1b) or intrinsic apoptosis and oncosis (1c). The localization of both compounds in the cytoplasm coupled to the absence of reactive oxygen species (ROS) induction suggest that the mechanisms of toxicity might be different than those of other anthracyclines currently used in chemotherapy.
N-Heterocyclic olefins as efficient phase-transfer catalysts for base-promoted alkylation reactions
Blümel, Marcus,Crocker, Reece D.,Harper, Jason B.,Enders, Dieter,Nguyen, Thanh V.
supporting information, p. 7958 - 7961 (2016/07/06)
N-Heterocyclic olefins (NHOs) have very recently emerged as efficient promoters for several chemical reactions due to their strong Br?nsted/Lewis basicities. Here we report the novel application of NHOs as efficient phase-transfer organocatalysts for synt