364328-07-4

Upstream product

• 1227210-37-8 6-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 7732-18-5 water 
• 1427407-16-6 tert-butyl N-tert-butoxycarbonyl-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)carbamate 
• 1427407-15-5 tert-butyl N-tert-butoxycarbonyl-N-[6-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate 
• 1427407-14-4 tert-butyl N-(3-bromo-6-fluoro-2-methylphenyl)-N-tert-butoxycarbonyl-carbamate 
• 1227210-36-7 3-bromo-6-fluoro-2-methyl-aniline 
• 3013-27-2 1-fluoro-3-methyl-2-nitro-benzene 
• 1227210-35-6 1-bromo-4-fluoro-2-methyl-3-nitro-benzene 

Downstream Products

• 1427407-17-7 2-fluoro-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)-5-(3-fluorophenyl)benzamide 
• 1427407-18-8 4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol 
• 1427407-19-9 C₂₄H₂₂F₃NO₃ 
• 1427406-13-0 2-[4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methylphenoxy]acetic acid 
• 1427407-84-8 4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)-3-methylphenyl]methylamino]-2-methylphenol 
• 1427407-85-9 C₂₆H₂₆F₃NO₃ 
• 1427406-31-2 C₂₃H₂₀F₃NO₃ 
• 1427407-87-1 4-fluoro-3-[[3-(3-fluorophenyl)-5-methyl-phenyl]methylamino]-2-methylphenol 
• 1427407-88-2 C₂₆H₂₇F₂NO₃ 
• 1427406-32-3 C₂₃H₂₁F₂NO₃ 
• 1427407-90-6 4-fluoro-3-[[5-(3-fluorophenyl)-2-methoxy-3-methylphenyl]methylamino]-2-methylphenol 
• 1427407-91-7 C₂₇H₂₉F₂NO₄ 
• 1427406-33-4 C₂₄H₂₃F₂NO₄ 
• 1427406-38-9 C₂₅H₂₄F₃NO₃ 

Relevant academic research and scientific papers

QUINAZOLINE COMPOUNDS

The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.