36433-01-9Relevant academic research and scientific papers
Function-oriented synthesis applied to the anti-botulinum natural product toosendanin
Nakai, Yuya,Tepp, William H.,Dickerson, Tobin J.,Johnson, Eric A.,Janda, Kim D.
, p. 1152 - 1157 (2009)
Botulinum neurotoxins (BoNTs) are the etiological agents responsible for botulism, a disease characterized by peripheral neuromuscular blockade and a characteristic flaccid paralysis of humans. The natural product toosendanin is a traditional Chinese medi
Synthesis of active antifeedant CDE fragments of 11- ketoepoxyazadiradione based on an electrocyclization reaction catalyzed by perchloric acid
Fernandez-Mateos, Alfonso,Martin De La Nava, Eva M.,Coca, Gustavo Pascual,Gonzalez, Rosa Rubio,Ramos Silvo, Ana I.,Simmonds,Blaney
, p. 9440 - 9447 (2007/10/03)
A synthetic route to mimics of the insect antifeedant epoxyazadiradione containing the CDE molecular fragment with an oxygenated function on ring C has been developed. The key step is based on a 2,6-diene-1,5-dione electrocyclization reaction catalyzed by perchloric acid. The rearrangement of the epoxy alcohol epimers 12 and 19 induced by acids deserves special mention. Several of the compounds obtained show significant antifeedant activity against Spodoptera frugiperda.
