36433-88-2

Upstream product

• 3946-91-6 N,N'-bis(salicylidene)-o-phenylenediamine 
• 6018-89-9 nickel(II) acetate tetrahydrate 
• 373-02-4 nickel diacetate 
• 90-02-8 salicylaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 36339-86-3 bis(3,6-dimethylsalicylaldehydato)nickel(II) 
• 21380-07-4 2,2′-((1E,1′E)-(1,2-phenylenebis(azanylylidene))bis(methanylylidene))diphenolzinc(II) 
• 83864-14-6 nickel dichloride 
• 7440-02-0 nickel 
• 3946-91-6 (E)-N,N'-bis(salicylidene)-1,2-phenylenediamine 
• 87655-40-1 (Ni(salophen)NaI(THF)0.5) 
• 14701-22-5 nickel(II) 

Downstream Products

• 80937-33-3 oxygen 
• 7440-02-0 nickel 
• 6846-97-5 poly[Ni(II) N,N'-bis(salicylidene)-o-phenylenediamine] 
• 1313-99-1 nickel(II) oxide 

Relevant academic research and scientific papers

Catalysis of alkene hydrogenation and oxidation by nickel-saloph complex; a novel bifunctional catalyst

Hydrogenation of cyclohexene to cyclohexane and cyclooctene to cyclooctane with H2 in presence of Ni(saloph), 1, (saloph= bis(salicylaldehyde)-o-phenylenediamine) were carried out at moderately high pressure (60 atm) and temperature (50°C) in ethanol medium. At normal temperature and pressure, the same catalyst (complex 1) catalyses the epoxidation of cyclohexene and cyclooctene with KHSO5 in presence of CTAB (cetyl trimethyl ammonium bromide; a phase-transfer reagent) in CH2Cl2. Cyclohexene oxide and cyclooctene oxide were found to be the major products of the epoxidation reactions.

Elastic Crystalline Fibers Composed of a Nickel(II) Complex

The generation of elastic crystalline fibers from a nonfibrous crystal of metal complex is demonstrated. Applying mechanical stimuli to a platelike crystal of NiII(salophen) [1; H2salophen = N,N′-bis(salicylidene)-o-phenylenediamine] resulted in this complex being transformed into crystal fibers, which could be bent into a loop and demonstrated its high elasticity. Single-crystal X-ray diffraction analyses revealed that the transformation reflects the presence of molecular strands that are composed of a one-dimensional assembly of the slip-stacked arrangement by nearly planar Ni(salophen) molecules. The fiber flexibility was demonstrated to be lost upon the introduction of chloroform solvent molecules into the crystal lattice by recrystallization.

Synthesis, characterization, antimicrobial, BSA binding, DFT calculation, molecular docking and cytotoxicity of Ni(II) complexes with Schiff base ligands

A series of a tetradentate N2O2 Schiff base ligands (1a-e), [N,N′-(X)bis(salicylidene)1,2-phenylenediamine], salphens {where X = H (1a), Cl (1b), Br (1c), CH3 (1d), OCH3(1e)} were synthesized from condensation of substituted salicylaldehydes with 1,2-phenylenediamine and nickel(II) complexes(2a-e) from corresponding Schiff base ligands(1a-e). The stoichiometric ratios of the prepared ligands (1a-e) and their Ni(II)-salphen complexes (2a-e) were structurally characterized by various analytical and spectroscopic techniques such as 1H NMR, FT-IR, mass, UV‐–visible, PXRD, magnetic moments and molar conductivity measurements. These results suggest that Ni(II)-salphen complexes (2a-e) have square planar geometry. The molar conductivity measurements indicate that all complexes (2a-e) are non-electrolytes. Density Functional Theory (DFT) calculations have been used to investigate the optimized structure and chemical reactivity of these Ni(II) complexes(2a-e) from their Frontier Molecular Orbitals (FMO). The binding capabilities of the Ni(II) Schiff base complexes (2a-e) with Bovine Serum Albumin (BSA) have been studied through electronic absorption, fluorescence and cyclic voltammetric methods. Further the nature of interaction of Ni(II) complexes (2a-e) towards BSA were confirmed using molecular docking analyses. All these results demonstrated that the Ni(II) complexes 2d and 2e have better binding affinity towards BSA among all the Ni(II) complexes. The antimicrobial studies reveal that the Ni(II)-salphen complexes (2a-e) have higher inhibitory effect than ligands (1a-e) against the selected pathogenic microorganisms. Furthermore, in vitro cytotoxicity of ligands (1a-e) and Ni(II) complexes(2a-e) were evaluated by MTT assay against MCF-7. The observed IC50 values against MCF-7 cell lines suggest that Ni(II) complexes(2a-e) show more significant anticancer activity than their corresponding ligands(1a-e). It is explored that complexes 2d and 2e bearing electron donating groups have greater anticancer potency. Comparison of our results with cisplatin, Zn(II)-salphen and V(IV)-salphen complexes indicated that Ni(II)-salphen complexes can be considered as the potential candidates for use as effective anticancer agent in future.

Zeolite encapsulated Ni(ii) Schiff-base complexes: improved catalysis and site isolation

Two series of zeolite encapsulated Ni(ii) Schiff-base complexes,i.e., the Ni(ii) sal-1,2-phen and Ni(ii) sal-1,3-phen series, have been synthesized in neat and encapsulated states and characterized by using different characterization techniques such as XRD, SEM-EDS, BET, thermal analysis, XPS, IR spectroscopy, UV-vis spectroscopy and magnetic studies. UV-vis spectroscopy, XPS and magnetic studies all together reveal the structural modification of the guest complex and, thereby, the adaptation of electron density around the metal center upon encapsulation. However, encapsulation causes structural alterations for these two series differently and, hence, introduces a certain level of proficiency to these Ni(ii) complexes as catalysts for phenol oxidation reaction. However, analysis of catalytic data emphasizes site isolation as a major governing factor for the improved reactivity over the modified electron density around the metal center for phenol oxidation reaction where the heterogeneous mode of catalysis is concerned.

A simple and efficient mechanochemical route for the synthesis of salophen ligands and of the corresponding Zn, Ni, and Pd complexes

A number of salophen ligands and their Zn, Ni, and Pd complexes were synthesized by an efficient one-pot mechanosynthesis protocol. The reaction products were characterized by means of complementary solid-state techniques, i.e., powder X-ray diffraction,

Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors

In this report, we designed and synthesized a series of cobalt(II)-Schiff base complexes (CoSBC) with competent MEK1 (mitogen-activated protein kinase kinase?1) inhibitory activity. Based on our previous report, the CoSBC exhibited high binding affinity with MEK1 protein. To further explore metal complexes as MEK1 inhibitors, a series of transition metals and ligands were employed to build a library of various metal Schiff base complexes. The MEK inhibition assays revealed that only CoSBC exhibited obvious inhibitory activity, complex 2b showed the best inhibition both in BRaf (B-rapidly accelerated fibrosarcoma)/MEK1 and MEK1/ERK2 (extracellular signal-regulated kinases-2) cascading (IC50 is 1.988 ± 0.14 μM and 1.589 ± 0.054 μM respectively). In addition, homogeneous time-resolved fluorescence test method was used to prove that CoSBC as ATP-noncompetitive MEK1 inhibitor. MEK kinase selectivity assay indicated that CoSBC can selectively inhibit MEK1/2 kinases rather than other MAPKs (mitogen-activated protein kinases) family kinases. Moreover, the interaction mode of 2b with MEK1 protein has been demonstrated by computer aided drug design.

Homogeneous photochemical water oxidation with metal salophen complexes in neutral media

The development of water oxidation catalysts based on Earth-abundant metals that can function at neutral pH remains a basic chemical challenge. Here, we report that salophen complexes with Ni(ii), Cu(ii), and Mn(ii) can catalyse photochemical water oxidat

Air-Stable Cobalt(II) and Nickel(II) Complexes with Schiff Base Ligand for Catalyzing Suzuki–Miyaura Cross-Coupling Reaction

The Co(II) complex [Co{C6H4–1,2-(N=CH–C6H4O)2}] (I) and Ni(II) complex [Ni{C6H4–1,2-(N=CH–C6H4O)2}] (II) with Schiff base of o-phenylenediamine and salicylaldehyde have been synthesized. The structure of the ligand and its complexes were derived on the basis of various techniques such as elemental analysis, mass, FT-IR, electronic spectra and magnetic susceptibility. From the Singal crystal X-ray diffraction (SCXRD) analysis techniques (CIF file CCDC no. 1498772 (II)), it has been confirmed that the Schiff base ligand (L), coordinates to the metal ion in a tetradentate fashion through the nitrogen and oxygen atom. In addition, the square planar geometry of Ni(II) complex also has been confirmed from SCXRD. Electronic spectra, mass spectra, and magnetic susceptibility measurements reveal square planar geometry for the Co(II) complex. Synthesized complexes were used in cross-coupling of arylhalides with phenylboronic acid. The transformation offers products in good yields using 0.02 mmol catalysts loading, thereby proving the efficiency of the complexes as catalysts for Suzuki–Miyaura reaction.

A Straightforward Electrochemical Approach to Imine- and Amine-bisphenolate Metal Complexes with Facile Control Over Metal Oxidation State

Synthetic methods to prepare organometallic and coordination compounds such as Schiff-base complexes are diverse, with the route chosen being dependent upon many factors such as metal–ligand combination and metal oxidation state. In this work we have shown that electrochemical methodology can be employed to synthesize a variety of metal–salen/salan complexes which comprise diverse metal–ligand combinations and oxidation states. Broad application has been demonstrated through the preparation of 34 complexes under mild and ambient conditions. Unprecedented control over metal oxidation state (MII/III/IVwhere M=Fe, Mn) is presented by simple modification of reaction conditions. Along this route, a general protocol-switch is described which allows access to analytically pure FeII/III–salen complexes. Tuning electrochemical potential, selective metalation of a Mn/Ni alloy is also presented which exclusively delivers MnII/IV–salen complexes in high yield.

Mechanistic study of the formation of multiblock π-conjugated metallopolymer

Electropolymerization of a π-conjugated polymer from [N,N′-bis(salicylidene)-o-phenylenediamine]nickel(II) complex ([Ni(salophen)]) on the surface of indium-tin-oxide (ITO) was studied. Two structures of the polymer have been proposed based on the theorem